7K0G
1.85 A resolution structure of SARS-CoV 3CL protease in complex with deuterated GC376
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Replicase polyprotein 1a | polymer | 310 | 34460.3 | 1 | UniProt (P0C6U8) Pfam (PF05409) In PDB | Human SARS coronavirus (SARS-CoV) | pp1a,ORF1a polyprotein |
2 | A | (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid | non-polymer | 485.6 | 1 | Chemie (K36) | |||
3 | A | (1R,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid | non-polymer | 485.6 | 1 | Chemie (B1S) | |||
4 | water | water | 18.0 | 127 | Chemie (HOH) |
Sequence modifications
A: 1 - 303 (UniProt: P0C6U8)
PDB | External Database | Details |
---|---|---|
Met -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
His -3 | - | expression tag |
His -2 | - | expression tag |
His -1 | - | expression tag |
His 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 34460.3 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 971.1 | |
All* | Total formula weight | 35431.4 |