7K0D
Crystal structure of the tandem bromodomain (BD1, BD2) of human TAF1 bound to mTORC1/2 inhibitor AZD3147
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Transcription initiation factor TFIID subunit 1 | polymer | 265 | 30968.3 | 1 | UniProt (P21675) Pfam (PF00439) In PDB | Homo sapiens (Human) | Cell cycle gene 1 protein,TBP-associated factor 250 kDa,p250,Transcription initiation factor TFIID 250 kDa subunit,TAFII250 |
| 2 | A | N-(4-{4-[1-(cyclopropylsulfonyl)cyclopropyl]-6-[(3S)-3-methylmorpholin-4-yl]pyrimidin-2-yl}phenyl)-N'-(2-hydroxyethyl)thiourea | non-polymer | 517.7 | 1 | Chemie (VQS) | |||
| 3 | water | water | 18.0 | 9 | Chemie (HOH) |
Sequence modifications
A: 1373 - 1635 (UniProt: P21675)
| PDB | External Database | Details |
|---|---|---|
| Ser 1371 | - | expression tag |
| Met 1372 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 30968.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 517.7 | |
| All* | Total formula weight | 31485.9 |
