7JX1

E. coli TSase complex with a bi-substrate reaction intermediate analog

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Thymidylate synthase	polymer	264	30559.7	2	UniProt (A0A029ILG4) Pfam (PF00303) UniProt (by SIFTS) (P0A884) In PDB	Escherichia coli	TSase
2	A	N-(4-{[(2,4-diamino-7,8-dihydropyrido[3,2-d]pyrimidin-6-yl)methyl]amino}benzene-1-carbonyl)-L-glutamic acid	non-polymer		441.4	1	Chemie (VLA)
3	A	THYMIDINE-5'-PHOSPHATE	non-polymer		322.2	1	Chemie (TMP)
4	B	(2S)-2-({4-[({(6R)-2,4-diamino-5-[(1-{(2R,4S,5R)-4-hydroxy-5-[(phosphonooxy)methyl]tetrahydrofuran-2-yl}-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)methyl]-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl}methyl)amino]benzoyl}amino)pentanedioic acid (non-preferred name)	non-polymer		763.6	1	Chemie (VLD)
5	B	PHOSPHATE ION	non-polymer		95.0	1	Chemie (PO4)
6		water	water		18.0	263	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	61119.3
Non-Polymers*	Number of molecules	4
	Total formula weight	1622.3
All*	Total formula weight	62741.6

*Water molecules are not included.