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7JX1

E. coli TSase complex with a bi-substrate reaction intermediate analog

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0003723molecular_functionRNA binding
A0004799molecular_functionthymidylate synthase activity
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006231biological_processdTMP biosynthetic process
A0006235biological_processdTTP biosynthetic process
A0006417biological_processregulation of translation
A0008168molecular_functionmethyltransferase activity
A0009165biological_processnucleotide biosynthetic process
A0009314biological_processresponse to radiation
A0016741molecular_functiontransferase activity, transferring one-carbon groups
A0032259biological_processmethylation
A0042803molecular_functionprotein homodimerization activity
B0000287molecular_functionmagnesium ion binding
B0003723molecular_functionRNA binding
B0004799molecular_functionthymidylate synthase activity
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006231biological_processdTMP biosynthetic process
B0006235biological_processdTTP biosynthetic process
B0006417biological_processregulation of translation
B0008168molecular_functionmethyltransferase activity
B0009165biological_processnucleotide biosynthetic process
B0009314biological_processresponse to radiation
B0016741molecular_functiontransferase activity, transferring one-carbon groups
B0032259biological_processmethylation
B0042803molecular_functionprotein homodimerization activity
Functional Information from PROSITE/UniProt
site_idPS00091
Number of Residues29
DetailsTHYMIDYLATE_SYNTHASE Thymidylate synthase active site. RriIvsaWNvgeldkma.....LaPCHaffQFyV
ChainResidueDetails
AARG126-VAL154

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Nucleophile => ECO:0000255|HAMAP-Rule:MF_00008, ECO:0000269|PubMed:2223754, ECO:0000269|PubMed:8973201, ECO:0000269|PubMed:9416600
ChainResidueDetails
ACYS146
BCYS146

site_idSWS_FT_FI2
Number of Residues8
DetailsBINDING: in other chain => ECO:0000269|PubMed:2223754, ECO:0000269|PubMed:8973201, ECO:0007744|PDB:1KCE, ECO:0007744|PDB:2TSC
ChainResidueDetails
BARG21
BARG166
BASN177
BHIS207
AARG21
AARG166
AASN177
AHIS207

site_idSWS_FT_FI3
Number of Residues6
DetailsBINDING: BINDING => ECO:0000305|PubMed:8312270, ECO:0007744|PDB:1TYS
ChainResidueDetails
AALA263
BHIS51
BASP169
BALA263
AHIS51
AASP169

site_idSWS_FT_FI4
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:2223754, ECO:0000269|PubMed:8973201, ECO:0007744|PDB:1KCE, ECO:0007744|PDB:2TSC
ChainResidueDetails
AARG126
BARG126

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PDB entries from 2024-05-29

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