7JTP

Crystal structure of Protac MS67 in complex with the WD repeat-containing protein 5 and pVHL:ElonginC:ElonginB

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	J	Elongin-B	polymer	104	11748.4	1	UniProt (Q15370) Pfam (PF00240) In PDB	Homo sapiens (Human)	EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2
2	K	Elongin-C	polymer	97	10974.6	1	UniProt (Q15369) Pfam (PF03931) In PDB	Homo sapiens (Human)	EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1
3	L	von Hippel-Lindau disease tumor suppressor	polymer	162	18702.3	1	UniProt (P40337) Pfam (PF01847) Pfam (PF17211) In PDB	Homo sapiens (Human)	Protein G7,pVHL
4	A	WD repeat-containing protein 5	polymer	308	34037.6	1	UniProt (P61964) Pfam (PF00400) In PDB	Homo sapiens (Human)	BMP2-induced 3-kb gene protein
5	A	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
6	A	N-(6-fluoro-3'-{[6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carbonyl]amino}-4'-[(3R,5S)-3,4,5-trimethylpiperazin-1-yl][1,1'-biphenyl]-3-carbonyl)glycyl-3-methyl-L-valyl-(4R)-4-hydroxy-N-{(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl}-L-prolinamide	non-polymer		1030.1	1	Chemie (X6M)
7		water	water		18.0	441	Chemie (HOH)

Sequence modifications

K: 17 - 112 (UniProt: Q15369)

PDB	External Database	Details
Met 16	-	initiating methionine

L: 54 - 213 (UniProt: P40337)

PDB	External Database	Details
Gly 52	-	expression tag
Ser 53	-	expression tag

A: 31 - 334 (UniProt: P61964)

PDB	External Database	Details
Glu 27	-	expression tag
Phe 28	-	expression tag
His 29	-	expression tag
Met 30	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	75463.0
Non-Polymers*	Number of molecules	2
	Total formula weight	1122.2
All*	Total formula weight	76585.2

*Water molecules are not included.