7JTP
Crystal structure of Protac MS67 in complex with the WD repeat-containing protein 5 and pVHL:ElonginC:ElonginB
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (J) | Elongin-B | polymer | 104 | 11748.4 | 1 | UniProt (Q15370) Pfam (PF00240) | Homo sapiens (Human) | EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2 |
| 2 | B (K) | Elongin-C | polymer | 97 | 10974.6 | 1 | UniProt (Q15369) Pfam (PF03931) | Homo sapiens (Human) | EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1 |
| 3 | C (L) | von Hippel-Lindau disease tumor suppressor | polymer | 162 | 18702.3 | 1 | UniProt (P40337) Pfam (PF01847) Pfam (PF17211) | Homo sapiens (Human) | Protein G7,pVHL |
| 4 | D (A) | WD repeat-containing protein 5 | polymer | 308 | 34037.6 | 1 | UniProt (P61964) Pfam (PF00400) | Homo sapiens (Human) | BMP2-induced 3-kb gene protein |
| 5 | E (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 6 | F (A) | N-(6-fluoro-3'-{[6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carbonyl]amino}-4'-[(3R,5S)-3,4,5-trimethylpiperazin-1-yl][1,1'-biphenyl]-3-carbonyl)glycyl-3-methyl-L-valyl-(4R)-4-hydroxy-N-{(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl}-L-prolinamide | non-polymer | 1030.1 | 1 | Chemie (X6M) | |||
| 7 | G, H, I, J (J, K, L, A) | water | water | 18.0 | 441 | Chemie (HOH) |
Sequence modifications
K: 17 - 112 (UniProt: Q15369)
L: 54 - 213 (UniProt: P40337)
A: 31 - 334 (UniProt: P61964)
| PDB | External Database | Details |
|---|---|---|
| Met 16 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Gly 52 | - | expression tag |
| Ser 53 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Glu 27 | - | expression tag |
| Phe 28 | - | expression tag |
| His 29 | - | expression tag |
| Met 30 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 75463.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1122.2 | |
| All* | Total formula weight | 76585.2 |
