7JTP

Crystal structure of Protac MS67 in complex with the WD repeat-containing protein 5 and pVHL:ElonginC:ElonginB

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0000123	cellular_component	histone acetyltransferase complex
A	0001501	biological_process	skeletal system development
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0006094	biological_process	gluconeogenesis
A	0006325	biological_process	chromatin organization
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006357	biological_process	regulation of transcription by RNA polymerase II
A	0035064	molecular_function	methylated histone binding
A	0035097	cellular_component	histone methyltransferase complex
A	0042393	molecular_function	histone binding
A	0042800	molecular_function	histone H3K4 methyltransferase activity
A	0044545	cellular_component	NSL complex
A	0044665	cellular_component	MLL1/2 complex
A	0044666	cellular_component	MLL3/4 complex
A	0045722	biological_process	positive regulation of gluconeogenesis
A	0045815	biological_process	transcription initiation-coupled chromatin remodeling
A	0045893	biological_process	positive regulation of DNA-templated transcription
A	0045995	biological_process	regulation of embryonic development
A	0048188	cellular_component	Set1C/COMPASS complex
A	0051302	biological_process	regulation of cell division
A	0051726	biological_process	regulation of cell cycle
A	0071339	cellular_component	MLL1 complex
A	0072686	cellular_component	mitotic spindle
A	0090043	biological_process	regulation of tubulin deacetylation
A	0140672	cellular_component	ATAC complex
J	0006368	biological_process	transcription elongation by RNA polymerase II
J	0030891	cellular_component	VCB complex
J	0070449	cellular_component	elongin complex
K	0006511	biological_process	ubiquitin-dependent protein catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue GOL A 401

Chain	Residue
A	ASN130
A	TYR131
A	PHE149
A	X6M402
A	HOH544

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site_id	AC2
Number of Residues	33
Details	binding site for residue X6M A 402

Chain	Residue
A	SER91
A	ASP92
A	ASP107
A	PHE133
A	PHE149
A	PRO173
A	SER175
A	TYR191
A	CYS261
A	ILE305
A	LEU321
A	GOL401
A	HOH560
A	HOH584
A	HOH614
A	HOH633
L	ARG69
L	TRP88
L	PHE91
L	TYR98
L	PRO99
L	ARG107
L	ILE109
L	HIS110
L	SER111
L	TYR112
L	HIS115
L	TRP117
L	HOH319
A	SER49
A	SER50
A	ALA65
A	GLY89

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Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsdDkTLKIWDV

Chain	Residue	Details
A	LEU102-VAL116
A	ILE144-VAL158
A	ILE186-THR200
A	ILE274-LEU288

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	SITE: Important for interaction with histone H3

Chain	Residue	Details
A	ASP107
A	PHE133
A	PHE263
A	GLU322

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	LYS112

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site_id	SWS_FT_FI3
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS46

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