7JQW
The external aldimine crystal structure of Salmonella typhimurium Tryptophan Synthase mutant beta-S377A in complex with cesium ion at the metal coordination site. The single beta-Q114 rotamer conformation allows a hydrogen bond to form with the PLP oxygen at the position 3 in the ring
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tryptophan synthase alpha chain | polymer | 268 | 28698.8 | 1 | UniProt (P00929) Pfam (PF00290) | Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) | |
| 2 | B (B) | Tryptophan synthase beta chain | polymer | 397 | 42902.9 | 1 | UniProt (P0A2K1) Pfam (PF00291) | Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) | |
| 3 | C, D, E, F, G... (A, B) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 18 | Chemie (DMS) | |||
| 4 | H, Y (A, B) | 2-AMINOPHENOL | non-polymer | 109.1 | 2 | Chemie (2AF) | |||
| 5 | DA, EA, FA, GA, HA... (B, A) | CHLORIDE ION | non-polymer | 35.5 | 12 | Chemie (CL) | |||
| 6 | AA (B) | (E)-N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-L-serine | non-polymer | 334.2 | 1 | Chemie (KOU) | |||
| 7 | BA (B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 8 | CA (B) | SERINE | non-polymer | 105.1 | 1 | Chemie (SER) | |||
| 9 | LA, MA (B) | CESIUM ION | non-polymer | 132.9 | 2 | Chemie (CS) | |||
| 10 | NA, OA (A, B) | water | water | 18.0 | 404 | Chemie (HOH) |
Sequence modifications
B: 1 - 397 (UniProt: P0A2K1)
| PDB | External Database | Details |
|---|---|---|
| Ala 377 | Ser 377 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 71601.7 | |
| Non-Polymers* | Number of molecules | 37 |
| Total formula weight | 2817.3 | |
| All* | Total formula weight | 74418.9 |
