7JQV
Crystal structure of the R64F mutant of Bauhinia Bauhinioides Kallikrein Inhibitor complexed with Human Kallikrein 4
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (E) | Kallikrein 4 (Prostase, enamel matrix, prostate), isoform CRA_a | polymer | 223 | 23926.0 | 1 | UniProt (A0A0C4DFQ5) Pfam (PF00089) UniProt (by SIFTS) (Q9Y5K2) | Homo sapiens (Human) | Kallikrein B1,Kallikrein-4 |
| 2 | B (I) | Kunitz-type inihibitor | polymer | 166 | 18130.5 | 1 | UniProt (Q6VEQ7) Pfam (PF00197) UniProt (by SIFTS) (P83052) | Bauhinia bauhinioides | |
| 3 | C, D, E (E, I) | NONAETHYLENE GLYCOL | non-polymer | 414.5 | 3 | Chemie (2PE) | |||
| 4 | F, G (I) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 5 | H, I (E, I) | water | water | 18.0 | 510 | Chemie (HOH) |
Sequence modifications
I: 1 - 165 (UniProt: Q6VEQ7)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Phe 64 | Arg 82 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 42056.5 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1314.4 | |
| All* | Total formula weight | 43370.9 |
