7JQC

SARS-CoV-2 Nsp1, CrPV IRES and rabbit 40S ribosome complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	rRNA	polymer	1869	602777.9	1		Oryctolagus cuniculus (Rabbit)
2	B (a)	eS25	polymer	125	13776.2	1	UniProt (G1TDB3) Pfam (PF03297)	Oryctolagus cuniculus (Rabbit)
3	C (B)	40S ribosomal protein SA	polymer	295	32958.0	1	UniProt (G1TLT8) Pfam (PF00318) Pfam (PF16122)	Oryctolagus cuniculus (Rabbit)	37 kDa laminin receptor precursor,37LRP,37/67 kDa laminin receptor,LRP/LR,67 kDa laminin receptor,67LR,Laminin receptor 1,LamR,Laminin-binding protein precursor p40,LBP/p40
4	D (b)	40S ribosomal protein S26	polymer	115	13047.5	1	UniProt (G1TFE8) Pfam (PF01283)	Oryctolagus cuniculus (Rabbit)
5	E (C)	eS1	polymer	264	30002.1	1	UniProt (G1SS70) Pfam (PF01015)	Oryctolagus cuniculus (Rabbit)	40S ribosomal protein S3a
6	F (D)	uS5	polymer	293	31327.4	1	Pfam (PF00333) Pfam (PF03719) UniProt (by SIFTS) (P15880)	Oryctolagus cuniculus (Rabbit)
7	G (d)	eS28	polymer	69	7855.1	1	UniProt (G1TIB4) Pfam (PF01200)	Oryctolagus cuniculus (Rabbit)	Ribosomal protein S28
8	H (E)	Ribosomal protein S3	polymer	243	26715.3	1	UniProt (G1TNM3) Pfam (PF07650) Pfam (PF00189)	Oryctolagus cuniculus (Rabbit)
9	I (f)	eS30	polymer	133	14498.9	1	UniProt (G1T8A2) Pfam (PF00240) Pfam (PF04758)	Oryctolagus cuniculus (Rabbit)	40S ribosomal protein S30
10	J (G)	uS7	polymer	204	22913.5	1	UniProt (G1TFM5) Pfam (PF00177)	Oryctolagus cuniculus (Rabbit)	40S ribosomal protein S5
11	K (g)	eS31	polymer	156	18004.0	1	UniProt (G1SK22) Pfam (PF00240) Pfam (PF01599) UniProt (by SIFTS) (P62979)	Oryctolagus cuniculus (Rabbit)	Ribosomal protein S27a
12	L (H)	eS6	polymer	249	28751.9	1	UniProt (G1TM55) Pfam (PF01092) UniProt (by SIFTS) (A0A5K1UJS7)	Oryctolagus cuniculus (Rabbit)	40S ribosomal protein S6
13	M (h)	RACK1	polymer	317	35115.7	1	UniProt (G1SJB4) Pfam (PF00400)	Oryctolagus cuniculus (Rabbit)
14	N (I)	eS7	polymer	194	22168.9	1	UniProt (G1SVB0)	Oryctolagus cuniculus (Rabbit)	40S ribosomal protein S7
15	O (J)	eS8	polymer	208	24263.4	1	UniProt (G1TJW1) Pfam (PF01201)	Oryctolagus cuniculus (Rabbit)	40S ribosomal protein S8
16	P (K)	uS4	polymer	194	22641.6	1	UniProt (B7NZS8) Pfam (PF00163) Pfam (PF01479)	Oryctolagus cuniculus (Rabbit)	Ribosomal protein S9
17	Q (L)	S10_plectin domain-containing protein	polymer	165	18933.8	1	UniProt (G1TPV3) Pfam (PF03501) UniProt (by SIFTS) (G1T168)	Oryctolagus cuniculus (Rabbit)
18	R (N)	eS12	polymer	132	14539.0	1	UniProt (G1SFR8) Pfam (PF01248)	Oryctolagus cuniculus (Rabbit)	40S ribosomal protein S12
19	S (Q)	uS19	polymer	145	17049.2	1	UniProt (G1U0Q2) Pfam (PF00203)	Oryctolagus cuniculus (Rabbit)
20	T (R)	Uncharacterized protein	polymer	146	16477.4	1	UniProt (G1SGX4) Pfam (PF00380)	Oryctolagus cuniculus (Rabbit)
21	U (S)	eS17	polymer	135	15552.1	1	UniProt (G1TU13) Pfam (PF00833)	Oryctolagus cuniculus (Rabbit)
22	V (T)	uS13	polymer	152	17759.8	1	UniProt (G1TPG3) Pfam (PF00416)	Oryctolagus cuniculus (Rabbit)
23	W (U)	Uncharacterized protein	polymer	145	16106.6	1	UniProt (G1TN62) Pfam (PF01090)	Oryctolagus cuniculus (Rabbit)
24	X (V)	uS10	polymer	119	13398.8	1	UniProt (G1SIZ2) Pfam (PF00338)	Oryctolagus cuniculus (Rabbit)
25	Y (W)	40S ribosomal protein S21	polymer	83	9124.4	1	UniProt (G1TM82) Pfam (PF01249) UniProt (by SIFTS) (P63220)	Oryctolagus cuniculus (Rabbit)
26	Z (Z)	40S ribosomal protein S24	polymer	130	15107.9	1	UniProt (A0A5F9CBF4) Pfam (PF01282) UniProt (by SIFTS) (A0A5F9D2E6)	Oryctolagus cuniculus (Rabbit)
27	AA (F)	Host translation inhibitor nsp1	polymer	36	4100.4	1	UniProt (P0DTD1)	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)	Leader protein,Non-structural protein 1,nsp1
28	BA (i)	Cricket paralysis virus IRES RNA	polymer	192	61462.2	1	GenBank (8895506)	Cricket paralysis virus
29	CA (M)	40S ribosomal protein S4	polymer	263	29658.9	1	UniProt (G1TK17) Pfam (PF08071) Pfam (PF00900) Pfam (PF00467) Pfam (PF16121)	Oryctolagus cuniculus (Rabbit)
30	DA (O)	uS17	polymer	158	18468.8	1	UniProt (G1TRM4) Pfam (PF16205) Pfam (PF00366)	Oryctolagus cuniculus (Rabbit)	40S ribosomal protein S11
31	EA (P)	uS15	polymer	151	17259.4	1	UniProt (G1SP51) Pfam (PF08069) Pfam (PF00312) UniProt (by SIFTS) (P62277)	Oryctolagus cuniculus (Rabbit)	Ribosomal protein S13
32	FA (X)	Uncharacterized protein	polymer	168	18134.0	1	UniProt (G1U472) Pfam (PF00411) UniProt (by SIFTS) (G1T1F0)	Oryctolagus cuniculus (Rabbit)
33	GA (Y)	uS8	polymer	130	14865.6	1	UniProt (G1TG89) Pfam (PF00410)	Oryctolagus cuniculus (Rabbit)	Ribosomal protein S15a
34	HA (c)	Uncharacterized protein	polymer	143	15844.7	1	UniProt (G1SZ47) Pfam (PF00164)	Oryctolagus cuniculus (Rabbit)
35	IA (e)	eS27	polymer	84	9480.2	1	UniProt (G1TZ76) Pfam (PF01667)	Oryctolagus cuniculus (Rabbit)	40S ribosomal protein S27

Sequence modifications

B: 1 - 295 (UniProt: G1TLT8)

PDB	External Database	Details
Thr 114	Ala 114	conflict

b: 1 - 115 (UniProt: G1TFE8)

PDB	External Database	Details
Arg 28	Cys 28	conflict
Ala 56	Val 56	conflict
Arg 109	Pro 109	conflict

J: 1 - 208 (UniProt: G1TJW1)

PDB	External Database	Details
Arg 47	Gly 47	conflict

U: 1 - 145 (UniProt: G1TN62)

PDB	External Database	Details
Gly 119	Trp 119	conflict

W: 1 - 83 (UniProt: G1TM82)

PDB	External Database	Details
Asn 3	Ser 3	conflict
Asp 4	Asn 4	conflict
Gln 33	Pro 33	conflict
Phe 50	Ser 50	conflict
Ala 75	Ser 75	conflict
Asp 76	His 76	conflict
Lys 81	Gln 81	conflict

i: 6030 - 6221 (GenBank: 8895506)

PDB	External Database	Details
C 6176	U 6176	conflict

Contents of the asymmetric unit

Polymers	Number of chains	35
	Total formula weight	1290140.4
All*	Total formula weight	1290140.4

*Water molecules are not included.