7JK7
Crystal structure of Importin alpha 2 in complex with LSD1 NLS S111E mutant
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Lysine-specific histone demethylase 1A | polymer | 26 | 3186.6 | 1 | UniProt (O60341) | Homo sapiens (Human) | BRAF35-HDAC complex protein BHC110,Flavin-containing amine oxidase domain-containing protein 2,[histone H3]-dimethyl-L-lysine(4) FAD-dependent demethylase 1A |
| 2 | B (B) | Importin subunit alpha-1 | polymer | 470 | 50970.8 | 1 | UniProt (P52293) Pfam (PF01749) Pfam (PF00514) Pfam (PF16186) | Mus musculus (Mouse) | Importin alpha P1,Karyopherin subunit alpha-2,Pendulin,Pore targeting complex 58 kDa subunit,PTAC58,RAG cohort protein 1,SRP1-alpha |
| 3 | C, D, E, F (B) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 150 | Chemie (HOH) |
Sequence modifications
A: 104 - 129 (UniProt: O60341)
B: 62 - 529 (UniProt: P52293)
| PDB | External Database | Details |
|---|---|---|
| Glu 111 | Ser 111 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 530 | - | expression tag |
| Ser 531 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 54157.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 368.4 | |
| All* | Total formula weight | 54525.7 |
