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7JK1

Human PrimPol inserting correct dCTP opposite the 8-oxoguanine lesion

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(A, B)
DNA-directed primase/polymerase proteinpolymer35441038.52UniProt (Q96LW4)
Pfam (PF01896)
Homo sapiens (Human)hPrimpol1,Coiled-coil domain-containing protein 111
2C, F
(C, G)
DNA (5'-D(P*AP*(8OG)P*CP*GP*CP*TP*AP*CP*CP*AP*CP*AP*CP*CP*CP*C)-3')polymer175078.32synthetic construct
3D, E
(D, F)
DNA (5'-D(*GP*GP*TP*GP*TP*GP*GP*TP*AP*GP*CP*G)-3')polymer123774.42synthetic construct
4G, L
(A, B)
2'-DEOXYCYTIDINE-5'-TRIPHOSPHATEnon-polymer467.22Chemie (DCP)
5H, M
(A, B)
CALCIUM IONnon-polymer40.12Chemie (CA)
6I, J, N
(A, B)
GLYCEROLnon-polymer92.13Chemie (GOL)
7K
(A)
DI(HYDROXYETHYL)ETHERnon-polymer106.11Chemie (PEG)
8O, P, Q, R, S...
(A, B, C, D, F...)
waterwater18.092Chemie (HOH)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains6
Total formula weight99782.5
Non-Polymers*Number of molecules8
Total formula weight1396.9
All*Total formula weight101179.3
*Water molecules are not included.

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PDB entries from 2025-06-11

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