7FUP
Crystal Structure of human cyclic GMP-AMP synthase in complex with methyl 1-benzoyl-3-methyl-5-(1,2-oxazol-5-yl)pyrazole-4-carboxylate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cyclic GMP-AMP synthase | polymer | 363 | 42536.1 | 1 | UniProt (Q8N884) Pfam (PF03281) Pfam (PF20266) | Homo sapiens (human) | cGAMP synthase,cGAS,h-cGAS,2'3'-cGAMP synthase,Mab-21 domain-containing protein 1 |
| 2 | B (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | C, D (A) | PROPANOIC ACID | non-polymer | 74.1 | 2 | Chemie (PPI) | |||
| 4 | E (A) | water | water | 18.0 | 50 | Chemie (HOH) |
Sequence modifications
A: 161 - 522 (UniProt: Q8N884)
| PDB | External Database | Details |
|---|---|---|
| Met 160 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 42536.1 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 213.6 | |
| All* | Total formula weight | 42749.7 |
