7FTN
Crystal Structure of human cyclic GMP-AMP synthase in complex with propanedioic acid
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cyclic GMP-AMP synthase | polymer | 362 | 42433.9 | 1 | UniProt (Q8N884) Pfam (PF03281) Pfam (PF20266) | Homo sapiens (human) | cGAMP synthase,cGAS,h-cGAS,2'3'-cGAMP synthase,Mab-21 domain-containing protein 1 |
| 2 | B (B) | DNA (5'-D(*AP*AP*AP*TP*TP*GP*CP*CP*GP*AP*AP*GP*AP*CP*GP*A)-3') | polymer | 16 | 4940.2 | 1 | synthetic construct | ||
| 3 | C (C) | DNA (5'-D(*TP*CP*GP*TP*CP*TP*TP*CP*GP*GP*CP*AP*AP*TP*T)-3') | polymer | 15 | 4551.0 | 1 | synthetic construct | ||
| 4 | D (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 5 | E (A) | MALONATE ION | non-polymer | 102.0 | 1 | Chemie (MLI) | |||
| 6 | F (A) | FORMIC ACID | non-polymer | 46.0 | 1 | Chemie (FMT) | |||
| 7 | G, H, I (A, B, C) | water | water | 18.0 | 227 | Chemie (HOH) |
Sequence modifications
A: 161 - 522 (UniProt: Q8N884)
| PDB | External Database | Details |
|---|---|---|
| Asn 187 | Lys 187 | conflict |
| Arg 195 | Leu 195 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 51925.1 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 213.5 | |
| All* | Total formula weight | 52138.5 |
