7FSB
Structure of liver pyruvate kinase in complex with allosteric modulator 41
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D, E... (A, B, C, D, E...) | Pyruvate kinase PKLR | polymer | 447 | 48285.4 | 8 | UniProt (P30613) Pfam (PF00224) Pfam (PF02887) | Homo sapiens (human) | Pyruvate kinase 1,Pyruvate kinase isozymes L/R,R-type/L-type pyruvate kinase,Red cell/liver pyruvate kinase |
2 | AA, EA, I, JA, N... (E, F, A, G, B...) | 1,6-di-O-phosphono-beta-D-fructofuranose | non-polymer | 340.1 | 8 | Chemie (FBP) | |||
3 | BA, FA, J, KA, O... (E, F, A, G, B...) | OXALATE ION | non-polymer | 88.0 | 8 | Chemie (OXL) | |||
4 | CA, GA, K, LA, P... (E, F, A, G, B...) | MAGNESIUM ION | non-polymer | 24.3 | 8 | Chemie (MG) | |||
5 | DA, HA, L, MA, Q... (E, F, A, G, B...) | POTASSIUM ION | non-polymer | 39.1 | 8 | Chemie (K) | |||
6 | IA, M, NA, R (F, A, G, B) | N-({4-[(3,4-dihydroxyphenyl)methyl]phenyl}methyl)-3,4-dihydroxybenzene-1-sulfonamide | non-polymer | 401.4 | 4 | Chemie (OE0) | |||
7 | SA, TA, UA, VA, WA... (A, B, C, D, E...) | water | water | 18.0 | 437 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H: 3 - 129 (UniProt: P30613)
A, B, C, D, E, F, G, H: 231 - 543 (UniProt: P30613)
PDB | External Database | Details |
---|---|---|
Gly -1 | - | expression tag |
Ser 0 | - | expression tag |
Met 1 | - | expression tag |
Glu 2 | - | expression tag |
Asp 12 | Ser 43 | conflict |
PDB | External Database | Details |
---|---|---|
Gly 130 | - | linker |
Ser 131 | - | linker |
Gly 132 | - | linker |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 386283.0 | |
Non-Polymers* | Number of molecules | 36 |
Total formula weight | 5538.0 | |
All* | Total formula weight | 391821.1 |