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7FSB

Structure of liver pyruvate kinase in complex with allosteric modulator 41

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, C, D, E...
(A, B, C, D, E...)
Pyruvate kinase PKLRpolymer44748285.48UniProt (P30613)
Pfam (PF00224)
Pfam (PF02887)
Homo sapiens (human)Pyruvate kinase 1,Pyruvate kinase isozymes L/R,R-type/L-type pyruvate kinase,Red cell/liver pyruvate kinase
2AA, EA, I, JA, N...
(E, F, A, G, B...)
1,6-di-O-phosphono-beta-D-fructofuranosenon-polymer340.18Chemie (FBP)
3BA, FA, J, KA, O...
(E, F, A, G, B...)
OXALATE IONnon-polymer88.08Chemie (OXL)
4CA, GA, K, LA, P...
(E, F, A, G, B...)
MAGNESIUM IONnon-polymer24.38Chemie (MG)
5DA, HA, L, MA, Q...
(E, F, A, G, B...)
POTASSIUM IONnon-polymer39.18Chemie (K)
6IA, M, NA, R
(F, A, G, B)
N-({4-[(3,4-dihydroxyphenyl)methyl]phenyl}methyl)-3,4-dihydroxybenzene-1-sulfonamidenon-polymer401.44Chemie (OE0)
7SA, TA, UA, VA, WA...
(A, B, C, D, E...)
waterwater18.0437Chemie (HOH)
Sequence modifications
A, B, C, D, E, F, G, H: 3 - 129 (UniProt: P30613)
PDBExternal DatabaseDetails
Gly -1-expression tag
Ser 0-expression tag
Met 1-expression tag
Glu 2-expression tag
Asp 12Ser 43conflict
A, B, C, D, E, F, G, H: 231 - 543 (UniProt: P30613)
PDBExternal DatabaseDetails
Gly 130-linker
Ser 131-linker
Gly 132-linker
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains8
Total formula weight386283.0
Non-Polymers*Number of molecules36
Total formula weight5538.0
All*Total formula weight391821.1
*Water molecules are not included.

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PDB entries from 2024-11-13

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