7FD0
Crystal Structure of human RIPK1 kinase domain in complex with a novel inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Receptor-interacting serine/threonine-protein kinase 1 | polymer | 297 | 33683.9 | 2 | UniProt (Q13546) Pfam (PF07714) | Homo sapiens (Human) | Cell death protein RIP,Receptor-interacting protein 1,RIP-1 |
| 2 | C, D (A, B) | N-[(3S)-5-methyl-7-[2-(oxan-4-yl)ethynyl]-4-oxidanylidene-2,3-dihydro-1,5-benzoxazepin-3-yl]-5-(phenylmethyl)-4H-1,2,4-triazole-3-carboxamide | non-polymer | 485.5 | 2 | Chemie (3IU) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 219 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 294 (UniProt: Q13546)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Ala -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Ala 34 | Cys 34 | engineered mutation |
| Ala 127 | Cys 127 | engineered mutation |
| Ala 233 | Cys 233 | engineered mutation |
| Ala 240 | Cys 240 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 67367.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 971.1 | |
| All* | Total formula weight | 68338.9 |
