7FD0
Crystal Structure of human RIPK1 kinase domain in complex with a novel inhibitor
Functional Information from GO Data
Functional Information from PROSITE/UniProt
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ViHkDLKpeNILV |
| Chain | Residue | Details |
| A | VAL134-VAL146 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 |
| Chain | Residue | Details |
| A | ASP138 | |
| B | ASP138 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 |
| Chain | Residue | Details |
| A | LEU23 | |
| A | LYS45 | |
| B | LEU23 | |
| B | LYS45 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by IKKA and IKKB => ECO:0000269|PubMed:18408713 |
| Chain | Residue | Details |
| A | SER6 | |
| B | SER6 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by autocatalysis => ECO:0000255 |
| Chain | Residue | Details |
| A | SER20 | |
| B | SER20 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by IKKA and IKKB => ECO:0000269|PubMed:18408713, ECO:0000269|PubMed:30988283 |
| Chain | Residue | Details |
| A | SER25 | |
| B | SER25 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by RIPK3 and autocatalysis => ECO:0000255 |
| Chain | Residue | Details |
| A | SER161 | |
| B | SER161 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by autocatalysis => ECO:0000255, ECO:0000269|PubMed:29440439, ECO:0000269|PubMed:31827280 |
| Chain | Residue | Details |
| A | SER166 | |
| B | SER166 |
