7F9M

Crystal structure of the variable region of Plasmodium RIFIN #4 (PF3D7_1000500) in complex with LAIR1 (with T67L, N69S and A77T mutations)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Rifin	polymer	175	18646.4	2	UniProt (A0A143ZWD5) Pfam (PF02009)	Plasmodium falciparum (isolate 3D7)
2	C, D (C, D)	Leukocyte-associated immunoglobulin-like receptor 1	polymer	112	12706.0	2	UniProt (Q6GTX8) Pfam (PF13895)	Homo sapiens (Human)	LAIR-1,hLAIR1

Sequence modifications

A, B: 157 - 323 (UniProt: A0A143ZWD5)

PDB	External Database	Details
His 149	-	expression tag
Met 150	-	expression tag
His 151	-	expression tag
His 152	-	expression tag
His 153	-	expression tag
His 154	-	expression tag
His 155	-	expression tag
His 156	-	expression tag

C, D: 22 - 122 (UniProt: Q6GTX8)

PDB	External Database	Details
His 14	-	expression tag
Met 15	-	expression tag
His 16	-	expression tag
His 17	-	expression tag
His 18	-	expression tag
His 19	-	expression tag
His 20	-	expression tag
His 21	-	expression tag
Leu 67	Thr 67	engineered mutation
Ser 69	Asn 69	engineered mutation
Thr 77	Ala 77	engineered mutation
Ala 123	-	expression tag
Ala 124	-	expression tag
Ala 125	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	62704.8
All*	Total formula weight	62704.8

*Water molecules are not included.