7F43
PARP15 catalytic domain in complex with Niraparib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Protein mono-ADP-ribosyltransferase PARP15 | polymer | 200 | 23025.8 | 2 | UniProt (Q460N3) Pfam (PF00644) In PDB | Homo sapiens (Human) | ADP-ribosyltransferase diphtheria toxin-like 7,ARTD7,B-aggressive lymphoma protein 3,Poly [ADP-ribose] polymerase 15,PARP-15 |
| 2 | B | 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide | non-polymer | 320.4 | 1 | Chemie (3JD) | |||
| 3 | water | water | 18.0 | 251 | Chemie (HOH) |
Sequence modifications
A, B: 481 - 678 (UniProt: Q460N3)
| PDB | External Database | Details |
|---|---|---|
| His 479 | - | expression tag |
| His 480 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 46051.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 320.4 | |
| All* | Total formula weight | 46372.0 |
