7F1R
Cryo-EM structure of the chemokine receptor CCR5 in complex with RANTES and Gi
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | R | C-C motif chemokine 5,C-C chemokine receptor type 5 | polymer | 462 | 52101.2 | 1 | UniProt (P13501) UniProt (P51681) Pfam (PF00048) Pfam (PF00001) In PDB | Homo sapiens (Human) | EoCP,Eosinophil chemotactic cytokine,SIS-delta,Small-inducible cytokine A5,T cell-specific protein P228,TCP228,T-cell-specific protein RANTES,C-C CKR-5,CC-CKR-5,CCR-5,CCR5,CHEMR13,HIV-1 fusion coreceptor |
2 | A | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 354 | 40447.1 | 1 | UniProt (P63096) Pfam (PF00503) In PDB | Homo sapiens (Human) | Adenylate cyclase-inhibiting G alpha protein |
3 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 340 | 37416.9 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (Human) | Transducin beta chain 1 |
4 | C | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (Human) | G gamma-I |
Sequence modifications
R: 1 - 68 (UniProt: P13501)
R: 97 - 414 (UniProt: P51681)
A: 1 - 354 (UniProt: P63096)
PDB | External Database | Details |
---|---|---|
Cys 28 | Phe 51 | engineered mutation |
Glu 69 | - | linker |
Phe 70 | - | linker |
Leu 71 | - | linker |
Glu 72 | - | linker |
Gly 73 | - | linker |
Ser 74 | - | linker |
Gly 75 | - | linker |
Ser 76 | - | linker |
Gly 77 | - | linker |
Ser 78 | - | linker |
Gly 79 | - | linker |
Ser 80 | - | linker |
Gly 81 | - | linker |
Ser 82 | - | linker |
Gly 83 | - | linker |
Ser 84 | - | linker |
Gly 85 | - | linker |
Ser 86 | - | linker |
Gly 87 | - | linker |
Ser 88 | - | linker |
Gly 89 | - | linker |
Ser 90 | - | linker |
Gly 91 | - | linker |
Ser 92 | - | linker |
Gly 93 | - | linker |
Ser 94 | - | linker |
Gly 95 | - | linker |
Ser 96 | - | linker |
PDB | External Database | Details |
---|---|---|
Asn 258 | Gly 163 | engineered mutation |
Cys 267 | Glu 172 | engineered mutation |
Glu 415 | - | expression tag |
Phe 416 | - | expression tag |
Leu 417 | - | expression tag |
Glu 418 | - | expression tag |
Val 419 | - | expression tag |
Leu 420 | - | expression tag |
Phe 421 | - | expression tag |
Gln 422 | - | expression tag |
Gly 423 | - | expression tag |
Pro 424 | - | expression tag |
Gly 425 | - | expression tag |
Ser 426 | - | expression tag |
Trp 427 | - | expression tag |
Ser 428 | - | expression tag |
His 429 | - | expression tag |
Pro 430 | - | expression tag |
Gln 431 | - | expression tag |
Phe 432 | - | expression tag |
Glu 433 | - | expression tag |
Lys 434 | - | expression tag |
Gly 435 | - | expression tag |
Ser 436 | - | expression tag |
Gly 437 | - | expression tag |
Ala 438 | - | expression tag |
Gly 439 | - | expression tag |
Ala 440 | - | expression tag |
Ser 441 | - | expression tag |
Ala 442 | - | expression tag |
Gly 443 | - | expression tag |
Ser 444 | - | expression tag |
Trp 445 | - | expression tag |
Ser 446 | - | expression tag |
His 447 | - | expression tag |
Pro 448 | - | expression tag |
Gln 449 | - | expression tag |
Phe 450 | - | expression tag |
Glu 451 | - | expression tag |
Lys 452 | - | expression tag |
Gly 453 | - | expression tag |
Ser 454 | - | expression tag |
Asp 455 | - | expression tag |
Tyr 456 | - | expression tag |
Lys 457 | - | expression tag |
Asp 458 | - | expression tag |
Asp 459 | - | expression tag |
Asp 460 | - | expression tag |
Asp 461 | - | expression tag |
Lys 462 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Cys 47 | Ser 47 | engineered mutation |
Thr 202 | Gly 202 | engineered mutation |
Ala 203 | Gly 203 | engineered mutation |
Ala 245 | Glu 245 | engineered mutation |
Ser 326 | Ala 326 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 137826.4 | |
All* | Total formula weight | 137826.4 |