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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7F0D

Cryo-EM structure of Mycobacterium tuberculosis 50S ribosome subunit bound with clarithromycin

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(0)		50S ribosomal protein L32polymer576525.81UniProt (A0A045IMI5)
Pfam (PF01783)
UniProt (by SIFTS) (A5U121)		Mycobacterium tuberculosis H37Ra
2B
(1)		50S ribosomal protein L33polymer556512.61UniProt (A0A045HU86)
Pfam (PF00471)
UniProt (by SIFTS) (A5U019)		Mycobacterium tuberculosis H37Ra
3C
(2)		50S ribosomal protein L34polymer475643.71UniProt (A0A3E0V610)
Pfam (PF00468)
UniProt (by SIFTS) (A5U9Q2)		Mycobacterium tuberculosis H37Ra
4D
(3)		50S ribosomal protein L35polymer647241.41UniProt (A0A045KKY9)
Pfam (PF01632)
UniProt (by SIFTS) (A5U2Z9)		Mycobacterium tuberculosis H37Ra
5E
(4)		50S ribosomal protein L36polymer374323.21UniProt (A0A3E0V5U0)
Pfam (PF00444)
UniProt (by SIFTS) (A5U8D7)		Mycobacterium tuberculosis H37Ra
6F
(6)		50S ribosomal protein L31polymer808770.11UniProt (A0A045HLX7)
Pfam (PF01197)
UniProt (by SIFTS) (A5U1Z7)		Mycobacterium tuberculosis H37Ra
7G
(A)		23S rRNApolymer31381017792.61GenBank (1251771536)Mycobacterium tuberculosis H37Ra
8H
(B)		5S ribosomal RNApolymer11537097.21GenBank (1251771551)Mycobacterium tuberculosis H37Ra
9I
(C)		50S ribosomal protein L2polymer28030644.01UniProt (A0A045H5T7)
Pfam (PF00181)
Pfam (PF03947)
UniProt (by SIFTS) (A5U090)		Mycobacterium tuberculosis H37Ra
10J
(D)		50S ribosomal protein L3polymer21723127.51UniProt (A0A045HU18)
Pfam (PF00297)
UniProt (by SIFTS) (A5U087)		Mycobacterium tuberculosis H37Ra
11K
(E)		50S ribosomal protein L4polymer22323779.91UniProt (A0A045J9H1)
Pfam (PF00573)
UniProt (by SIFTS) (A5U088)		Mycobacterium tuberculosis H37Ra
12L
(F)		50S ribosomal protein L5polymer18721052.31UniProt (A0A045HUU0)
Pfam (PF00281)
Pfam (PF00673)
UniProt (by SIFTS) (A5U0A2)		Mycobacterium tuberculosis H37Ra
13M
(G)		50S ribosomal protein L6polymer17919408.41UniProt (A0A045JJU1)
Pfam (PF00347)
UniProt (by SIFTS) (A5U0A5)		Mycobacterium tuberculosis H37Ra
14N
(H)		50S ribosomal protein L9polymer15216196.71UniProt (A0A045JW48)
Pfam (PF01281)
Pfam (PF03948)
UniProt (by SIFTS) (A5TYC7)		Mycobacterium tuberculosis H37Ra
15O
(J)		50S ribosomal protein L13polymer14716333.91UniProt (A0A0T9D5H2)
Pfam (PF00572)
UniProt (by SIFTS) (A5U8B9)		Mycobacterium tuberculosis H37Ra
16P
(K)		50S ribosomal protein L14polymer12213419.61UniProt (A0A045HTP7)
Pfam (PF00238)
UniProt (by SIFTS) (A5U0A0)		Mycobacterium tuberculosis H37Ra
17Q
(L)		50S ribosomal protein L15polymer14615534.11UniProt (A0A654TTE7)
Pfam (PF00828)
UniProt (by SIFTS) (A5U0A9)		Mycobacterium tuberculosis H37Ra
18R
(M)		50S ribosomal protein L16polymer13815724.31UniProt (A0A045IWV9)
Pfam (PF00252)
UniProt (by SIFTS) (A5U094)		Mycobacterium tuberculosis H37Ra
19S
(N)		50S ribosomal protein L17polymer18019512.31UniProt (A0A045IVA2)
Pfam (PF01196)
UniProt (by SIFTS) (A5U8D2)		Mycobacterium tuberculosis H37Ra
20T
(O)		50S ribosomal protein L18polymer12213211.11UniProt (A0A045JK28)
Pfam (PF00861)
UniProt (by SIFTS) (A5U0A6)		Mycobacterium tuberculosis H37Ra
21U
(P)		50S ribosomal protein L19polymer11313041.11UniProt (A0A045IDD2)
Pfam (PF01245)
UniProt (by SIFTS) (A5U6Q9)		Mycobacterium tuberculosis H37Ra
22V
(Q)		50S ribosomal protein L20polymer12914557.81UniProt (A0A045KJ85)
Pfam (PF00453)
UniProt (by SIFTS) (A5U300)		Mycobacterium tuberculosis H37Ra
23W
(R)		50S ribosomal protein L21polymer10411173.11UniProt (P9WHC3)
Pfam (PF00829)		Mycobacterium tuberculosis H37Ra
24X
(S)		50S ribosomal protein L22polymer19720424.61UniProt (A0A045H760)
Pfam (PF00237)
UniProt (by SIFTS) (A5U092)		Mycobacterium tuberculosis H37Ra
25Y
(T)		50S ribosomal protein L23polymer10010976.81UniProt (A0A045J9M3)
Pfam (PF00276)
UniProt (by SIFTS) (A5U089)		Mycobacterium tuberculosis H37Ra
26Z
(U)		50S ribosomal protein L24polymer10511500.31UniProt (A0A045IXU4)
Pfam (PF00467)
Pfam (PF17136)
UniProt (by SIFTS) (A5U0A1)		Mycobacterium tuberculosis H37Ra
27AA
(V)		50S ribosomal protein L25polymer21522466.21UniProt (A0A045JAK4)
Pfam (PF01386)
Pfam (PF14693)
UniProt (by SIFTS) (A5U158)		Mycobacterium tuberculosis H37RaGeneral stress protein CTC
28BA
(W)		50S ribosomal protein L27polymer868987.31UniProt (A0A045K0G1)
Pfam (PF01016)
UniProt (by SIFTS) (A5U5D7)		Mycobacterium tuberculosis H37Ra
29CA
(X)		50S ribosomal protein L28polymer646920.11UniProt (A0A045IDB8)
Pfam (PF00830)
UniProt (by SIFTS) (A5U6Y6)		Mycobacterium tuberculosis H37Ra
30DA
(Y)		50S ribosomal protein L29polymer778872.01UniProt (A0A045IQ64)
Pfam (PF00831)
UniProt (by SIFTS) (A5U095)		Mycobacterium tuberculosis H37Ra
31EA
(Z)		50S ribosomal protein L30polymer657361.61UniProt (A0A045H4J2)
Pfam (PF00327)
UniProt (by SIFTS) (A5U0A8)		Mycobacterium tuberculosis H37Ra
32FA
(A)		CLARITHROMYCINnon-polymer748.01Chemie (CTY)
PubChem (16757843)
PubChem (17753750)
PubChem (20704438)
PubChem (20849267)
PubChem (54688)
PubChem (22489167)
PubChem (22610576)
PubChem (22726642)
PubChem (71205175)
PubChem (23305082)
PubChem (44518313)
PubChem (44602425)
PubChem (24879875)
PubChem (489010)
PubChem (44324798)
PubChem (71207367)
PubChem (44629879)
PubChem (53384925)
PubChem (71222396)
PubChem (57587183)
PubChem (57893304)
PubChem (58593560)
PubChem (58648988)
PubChem (58668038)
PubChem (58668054)
PubChem (59008455)
PubChem (59022406)
PubChem (59077420)
PubChem (59077422)
PubChem (59109206)
PubChem (57642074)
PubChem (58385823)
PubChem (58839437)
PubChem (58668063)
PubChem (59451330)
PubChem (59848208)
PubChem (59890241)
PubChem (60086517)
PubChem (60111849)
PubChem (70789203)
PubChem (71296890)
PubChem (69014284)
PubChem (176519872)
PubChem (73265265)
PubChem (84029)
PubChem (89969195)
PubChem (90777825)
PubChem (10328822)
PubChem (11814635)
PubChem (89970515)
PubChem (11969952)
PubChem (13048688)
PubChem (13048692)
PubChem (13048697)
PubChem (91274974)
PubChem (91262038)
PubChem (4663848)
PubChem (5284534)
PubChem (99719292)
PubChem (99719293)
PubChem (99719291)
PubChem (99719294)
PubChem (5311050)
PubChem (118546736)
PubChem (6426662)
PubChem (118966928)
PubChem (121299034)
PubChem (123133950)
PubChem (124744630)
PubChem (9811194)
PubChem (9810688)
PubChem (143260342)
PubChem (124909231)
PubChem (125462873)
PubChem (125462871)
PubChem (129009994)
PubChem (10147055)
PubChem (131632320)
PubChem (133687876)
PubChem (134149294)
PubChem (121299689)
PubChem (134990236)
PubChem (11828745)
PubChem (12148640)
PubChem (124744627)
PubChem (124744628)
PubChem (124744629)
PubChem (124909232)
PubChem (124909233)
PubChem (124909234)
PubChem (137656238)
PubChem (137704810)
PubChem (138106927)
PubChem (125462863)
PubChem (125462875)
PubChem (129396774)
PubChem (139083133)
PubChem (13048687)
PubChem (129906904)
PubChem (131847083)
PubChem (141694302)
PubChem (145832159)
PubChem (133639588)
PubChem (146939478)
PubChem (134694742)
PubChem (154699474)
PubChem (134922511)
PubChem (156732645)
PubChem (157108618)
PubChem (160198343)
PubChem (162136103)
PubChem (163418652)
PubChem (167533397)
PubChem (140431934)
PubChem (157108619)
PubChem (157108620)
PubChem (173748470)
PubChem (173985446)
PubChem (162490686)
PubChem (166639083)
PubChem (171036966)
PubChem (173759178)
33GA
(A)		MAGNESIUM IONnon-polymer24.31Chemie (MG)
PubChem (888)
34HA
(A)		waterwater18.03Chemie (HOH)
Sequence modifications
4: 2 - 37 (UniProt: A0A3E0V5U0)
PDBExternal DatabaseDetails
Val 1-expression tag
K: 2 - 122 (UniProt: A0A045HTP7)
PDBExternal DatabaseDetails
Val 1-expression tag
L: 2 - 146 (UniProt: A0A654TTE7)
PDBExternal DatabaseDetails
Val 1-expression tag
R: 2 - 104 (UniProt: P9WHC3)
PDBExternal DatabaseDetails
Met 1-initiating methionine
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains31
Total formula weight1458131.4
Non-Polymers*Number of molecules2
Total formula weight772.3
All*Total formula weight1458903.7
*Water molecules are not included.

251422

PDB entries from 2026-04-01

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