7F0D
Cryo-EM structure of Mycobacterium tuberculosis 50S ribosome subunit bound with clarithromycin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (0) | 50S ribosomal protein L32 | polymer | 57 | 6525.8 | 1 | UniProt (A0A045IMI5) Pfam (PF01783) UniProt (by SIFTS) (A5U121) | Mycobacterium tuberculosis H37Ra | |
| 2 | B (1) | 50S ribosomal protein L33 | polymer | 55 | 6512.6 | 1 | UniProt (A0A045HU86) Pfam (PF00471) UniProt (by SIFTS) (A5U019) | Mycobacterium tuberculosis H37Ra | |
| 3 | C (2) | 50S ribosomal protein L34 | polymer | 47 | 5643.7 | 1 | UniProt (A0A3E0V610) Pfam (PF00468) UniProt (by SIFTS) (A5U9Q2) | Mycobacterium tuberculosis H37Ra | |
| 4 | D (3) | 50S ribosomal protein L35 | polymer | 64 | 7241.4 | 1 | UniProt (A0A045KKY9) Pfam (PF01632) UniProt (by SIFTS) (A5U2Z9) | Mycobacterium tuberculosis H37Ra | |
| 5 | E (4) | 50S ribosomal protein L36 | polymer | 37 | 4323.2 | 1 | UniProt (A0A3E0V5U0) Pfam (PF00444) UniProt (by SIFTS) (A5U8D7) | Mycobacterium tuberculosis H37Ra | |
| 6 | F (6) | 50S ribosomal protein L31 | polymer | 80 | 8770.1 | 1 | UniProt (A0A045HLX7) Pfam (PF01197) UniProt (by SIFTS) (A5U1Z7) | Mycobacterium tuberculosis H37Ra | |
| 7 | G (A) | 23S rRNA | polymer | 3138 | 1017792.6 | 1 | GenBank (1251771536) | Mycobacterium tuberculosis H37Ra | |
| 8 | H (B) | 5S ribosomal RNA | polymer | 115 | 37097.2 | 1 | GenBank (1251771551) | Mycobacterium tuberculosis H37Ra | |
| 9 | I (C) | 50S ribosomal protein L2 | polymer | 280 | 30644.0 | 1 | UniProt (A0A045H5T7) Pfam (PF00181) Pfam (PF03947) UniProt (by SIFTS) (A5U090) | Mycobacterium tuberculosis H37Ra | |
| 10 | J (D) | 50S ribosomal protein L3 | polymer | 217 | 23127.5 | 1 | UniProt (A0A045HU18) Pfam (PF00297) UniProt (by SIFTS) (A5U087) | Mycobacterium tuberculosis H37Ra | |
| 11 | K (E) | 50S ribosomal protein L4 | polymer | 223 | 23779.9 | 1 | UniProt (A0A045J9H1) Pfam (PF00573) UniProt (by SIFTS) (A5U088) | Mycobacterium tuberculosis H37Ra | |
| 12 | L (F) | 50S ribosomal protein L5 | polymer | 187 | 21052.3 | 1 | UniProt (A0A045HUU0) Pfam (PF00281) Pfam (PF00673) UniProt (by SIFTS) (A5U0A2) | Mycobacterium tuberculosis H37Ra | |
| 13 | M (G) | 50S ribosomal protein L6 | polymer | 179 | 19408.4 | 1 | UniProt (A0A045JJU1) Pfam (PF00347) UniProt (by SIFTS) (A5U0A5) | Mycobacterium tuberculosis H37Ra | |
| 14 | N (H) | 50S ribosomal protein L9 | polymer | 152 | 16196.7 | 1 | UniProt (A0A045JW48) Pfam (PF01281) Pfam (PF03948) UniProt (by SIFTS) (A5TYC7) | Mycobacterium tuberculosis H37Ra | |
| 15 | O (J) | 50S ribosomal protein L13 | polymer | 147 | 16333.9 | 1 | UniProt (A0A0T9D5H2) Pfam (PF00572) UniProt (by SIFTS) (A5U8B9) | Mycobacterium tuberculosis H37Ra | |
| 16 | P (K) | 50S ribosomal protein L14 | polymer | 122 | 13419.6 | 1 | UniProt (A0A045HTP7) Pfam (PF00238) UniProt (by SIFTS) (A5U0A0) | Mycobacterium tuberculosis H37Ra | |
| 17 | Q (L) | 50S ribosomal protein L15 | polymer | 146 | 15534.1 | 1 | UniProt (A0A654TTE7) Pfam (PF00828) UniProt (by SIFTS) (A5U0A9) | Mycobacterium tuberculosis H37Ra | |
| 18 | R (M) | 50S ribosomal protein L16 | polymer | 138 | 15724.3 | 1 | UniProt (A0A045IWV9) Pfam (PF00252) UniProt (by SIFTS) (A5U094) | Mycobacterium tuberculosis H37Ra | |
| 19 | S (N) | 50S ribosomal protein L17 | polymer | 180 | 19512.3 | 1 | UniProt (A0A045IVA2) Pfam (PF01196) UniProt (by SIFTS) (A5U8D2) | Mycobacterium tuberculosis H37Ra | |
| 20 | T (O) | 50S ribosomal protein L18 | polymer | 122 | 13211.1 | 1 | UniProt (A0A045JK28) Pfam (PF00861) UniProt (by SIFTS) (A5U0A6) | Mycobacterium tuberculosis H37Ra | |
| 21 | U (P) | 50S ribosomal protein L19 | polymer | 113 | 13041.1 | 1 | UniProt (A0A045IDD2) Pfam (PF01245) UniProt (by SIFTS) (A5U6Q9) | Mycobacterium tuberculosis H37Ra | |
| 22 | V (Q) | 50S ribosomal protein L20 | polymer | 129 | 14557.8 | 1 | UniProt (A0A045KJ85) Pfam (PF00453) UniProt (by SIFTS) (A5U300) | Mycobacterium tuberculosis H37Ra | |
| 23 | W (R) | 50S ribosomal protein L21 | polymer | 104 | 11173.1 | 1 | UniProt (P9WHC3) Pfam (PF00829) UniProt (by SIFTS) (A5U5D8) | Mycobacterium tuberculosis H37Ra | |
| 24 | X (S) | 50S ribosomal protein L22 | polymer | 197 | 20424.6 | 1 | UniProt (A0A045H760) Pfam (PF00237) UniProt (by SIFTS) (A5U092) | Mycobacterium tuberculosis H37Ra | |
| 25 | Y (T) | 50S ribosomal protein L23 | polymer | 100 | 10976.8 | 1 | UniProt (A0A045J9M3) Pfam (PF00276) UniProt (by SIFTS) (A5U089) | Mycobacterium tuberculosis H37Ra | |
| 26 | Z (U) | 50S ribosomal protein L24 | polymer | 105 | 11500.3 | 1 | UniProt (A0A045IXU4) Pfam (PF00467) Pfam (PF17136) UniProt (by SIFTS) (A5U0A1) | Mycobacterium tuberculosis H37Ra | |
| 27 | AA (V) | 50S ribosomal protein L25 | polymer | 215 | 22466.2 | 1 | UniProt (A0A045JAK4) Pfam (PF01386) Pfam (PF14693) UniProt (by SIFTS) (A5U158) | Mycobacterium tuberculosis H37Ra | General stress protein CTC |
| 28 | BA (W) | 50S ribosomal protein L27 | polymer | 86 | 8987.3 | 1 | UniProt (A0A045K0G1) Pfam (PF01016) UniProt (by SIFTS) (A5U5D7) | Mycobacterium tuberculosis H37Ra | |
| 29 | CA (X) | 50S ribosomal protein L28 | polymer | 64 | 6920.1 | 1 | UniProt (A0A045IDB8) Pfam (PF00830) UniProt (by SIFTS) (A5U6Y6) | Mycobacterium tuberculosis H37Ra | |
| 30 | DA (Y) | 50S ribosomal protein L29 | polymer | 77 | 8872.0 | 1 | UniProt (A0A045IQ64) Pfam (PF00831) UniProt (by SIFTS) (A5U095) | Mycobacterium tuberculosis H37Ra | |
| 31 | EA (Z) | 50S ribosomal protein L30 | polymer | 65 | 7361.6 | 1 | UniProt (A0A045H4J2) Pfam (PF00327) UniProt (by SIFTS) (A5U0A8) | Mycobacterium tuberculosis H37Ra | |
| 32 | FA (A) | CLARITHROMYCIN | non-polymer | 748.0 | 1 | Chemie (CTY) | |||
| 33 | GA (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 34 | HA (A) | water | water | 18.0 | 3 | Chemie (HOH) |
Sequence modifications
4: 2 - 37 (UniProt: A0A3E0V5U0)
K: 2 - 122 (UniProt: A0A045HTP7)
L: 2 - 146 (UniProt: A0A654TTE7)
R: 2 - 104 (UniProt: P9WHC3)
| PDB | External Database | Details |
|---|---|---|
| Val 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Val 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Val 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 31 |
| Total formula weight | 1458131.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 772.3 | |
| All* | Total formula weight | 1458903.7 |
