7EPD

Cryo-EM structure of inactive mGlu2-7 heterodimer

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Metabotropic glutamate receptor 2,Peptidylprolyl isomerase	polymer	947	104904.0	1	UniProt (Q14416) UniProt (Q0VDC6) Pfam (PF01094) Pfam (PF07562) Pfam (PF00003) Pfam (PF00254) UniProt (by SIFTS) (P62942)	Homo sapiens (Human)	mGluR2
2	B (B)	Isoform 3 of Metabotropic glutamate receptor 7	polymer	967	109243.7	1	Pfam (PF01094) Pfam (PF07562) Pfam (PF00003) Pfam (PF08771) UniProt (by SIFTS) (Q14831) UniProt (by SIFTS) (P42345)	Homo sapiens

Sequence modifications

A: 19 - 825 (UniProt: Q14416)

PDB	External Database	Details
Asp 9	-	expression tag
Tyr 10	-	expression tag
Lys 11	-	expression tag
Asp 12	-	expression tag
Asp 13	-	expression tag
Asp 14	-	expression tag
Asp 15	-	expression tag
Gly 16	-	expression tag
Ala 17	-	expression tag
Pro 18	-	expression tag
Tyr 655	Asn 655	engineered mutation
Tyr 815	His 815	engineered mutation
Ala 826	-	linker
Ala 827	-	linker
Ala 828	-	linker

A: 829 - 935 (UniProt: Q0VDC6)

PDB	External Database	Details
Glu 936	-	expression tag
Phe 937	-	expression tag
Leu 938	-	expression tag
Glu 939	-	expression tag
Val 940	-	expression tag
Leu 941	-	expression tag
Phe 942	-	expression tag
Gln 943	-	expression tag
Gly 944	-	expression tag
Pro 945	-	expression tag
His 946	-	expression tag
His 947	-	expression tag
His 948	-	expression tag
His 949	-	expression tag
His 950	-	expression tag
His 951	-	expression tag
His 952	-	expression tag
His 953	-	expression tag
His 954	-	expression tag
His 955	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	214147.7
All*	Total formula weight	214147.7

*Water molecules are not included.