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7EPD

Cryo-EM structure of inactive mGlu2-7 heterodimer

Functional Information from GO Data
ChainGOidnamespacecontents
A0000413biological_processprotein peptidyl-prolyl isomerization
A0001641molecular_functiongroup II metabotropic glutamate receptor activity
A0003007biological_processheart morphogenesis
A0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
A0004930molecular_functionG protein-coupled receptor activity
A0005160molecular_functiontransforming growth factor beta receptor binding
A0005246molecular_functioncalcium channel regulator activity
A0005515molecular_functionprotein binding
A0005527molecular_functionmacrolide binding
A0005528molecular_functionFK506 binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006457biological_processprotein folding
A0006458biological_process'de novo' protein folding
A0007186biological_processG protein-coupled receptor signaling pathway
A0007194biological_processnegative regulation of adenylate cyclase activity
A0007196biological_processadenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway
A0007215biological_processglutamate receptor signaling pathway
A0007216biological_processG protein-coupled glutamate receptor signaling pathway
A0007268biological_processchemical synaptic transmission
A0008066molecular_functionglutamate receptor activity
A0010467biological_processgene expression
A0014047biological_processglutamate secretion
A0014048biological_processregulation of glutamate secretion
A0014059biological_processregulation of dopamine secretion
A0014802cellular_componentterminal cisterna
A0014809biological_processregulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
A0016020cellular_componentmembrane
A0016247molecular_functionchannel regulator activity
A0016529cellular_componentsarcoplasmic reticulum
A0022417biological_processprotein maturation by protein folding
A0030018cellular_componentZ disc
A0030424cellular_componentaxon
A0030425cellular_componentdendrite
A0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
A0030547molecular_functionsignaling receptor inhibitor activity
A0032092biological_processpositive regulation of protein binding
A0032880biological_processregulation of protein localization
A0032926biological_processnegative regulation of activin receptor signaling pathway
A0033017cellular_componentsarcoplasmic reticulum membrane
A0034713molecular_functiontype I transforming growth factor beta receptor binding
A0035095biological_processbehavioral response to nicotine
A0042026biological_processprotein refolding
A0042110biological_processT cell activation
A0042220biological_processresponse to cocaine
A0042734cellular_componentpresynaptic membrane
A0042995cellular_componentcell projection
A0043005cellular_componentneuron projection
A0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
A0044325molecular_functiontransmembrane transporter binding
A0045202cellular_componentsynapse
A0050776biological_processregulation of immune response
A0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0051966biological_processregulation of synaptic transmission, glutamatergic
A0055010biological_processventricular cardiac muscle tissue morphogenesis
A0060292biological_processlong-term synaptic depression
A0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
A0060347biological_processheart trabecula formation
A0070411molecular_functionI-SMAD binding
A0070588biological_processcalcium ion transmembrane transport
A0070697molecular_functionactivin receptor binding
A0090461biological_processintracellular glutamate homeostasis
A0097110molecular_functionscaffold protein binding
A0097435biological_processsupramolecular fiber organization
A0097449cellular_componentastrocyte projection
A0098562cellular_componentcytoplasmic side of membrane
A0098978cellular_componentglutamatergic synapse
A0099171biological_processpresynaptic modulation of chemical synaptic transmission
A1902991biological_processregulation of amyloid precursor protein catabolic process
A1990000biological_processamyloid fibril formation
A1990425cellular_componentryanodine receptor complex
A2001023biological_processregulation of response to drug
B0004930molecular_functionG protein-coupled receptor activity
B0007186biological_processG protein-coupled receptor signaling pathway
B0016020cellular_componentmembrane
B0044877molecular_functionprotein-containing complex binding
Functional Information from PROSITE/UniProt
site_idPS00979
Number of Residues19
DetailsG_PROTEIN_RECEP_F3_1 G-protein coupled receptors family 3 signature 1. VaNLLrLFqIPQISyASTS
ChainResidueDetails
AVAL151-SER169
BVAL165-ALA183

site_idPS00980
Number of Residues23
DetailsG_PROTEIN_RECEP_F3_2 G-protein coupled receptors family 3 signature 2. CCWlCipCqpyeYrl...DefTCadC
ChainResidueDetails
ACYS518-CYS540
BCYS541-CYS563

site_idPS00981
Number of Residues11
DetailsG_PROTEIN_RECEP_F3_3 G-protein coupled receptors family 3 signature 3. FNEAKfIGFTM
ChainResidueDetails
APHE756-MET766
BPHE784-MET794

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues603
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
BTYR38-ILE593
BVAL652-PHE657
BASN727-ILE756
BSER814-SER828

site_idSWS_FT_FI2
Number of Residues24
DetailsTRANSMEM: Helical; Name=1 => ECO:0000255
ChainResidueDetails
BPRO594-THR618

site_idSWS_FT_FI3
Number of Residues49
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
BPRO619-TYR630
BARG679-ILE705
BGLY779-GLY791

site_idSWS_FT_FI4
Number of Residues20
DetailsTRANSMEM: Helical; Name=2 => ECO:0000255
ChainResidueDetails
BVAL631-ASP651

site_idSWS_FT_FI5
Number of Residues20
DetailsTRANSMEM: Helical; Name=3 => ECO:0000255
ChainResidueDetails
BARG658-ASN678

site_idSWS_FT_FI6
Number of Residues20
DetailsTRANSMEM: Helical; Name=4 => ECO:0000255
ChainResidueDetails
BTHR706-PRO726

site_idSWS_FT_FI7
Number of Residues21
DetailsTRANSMEM: Helical; Name=5 => ECO:0000255
ChainResidueDetails
BILE757-ARG778

site_idSWS_FT_FI8
Number of Residues21
DetailsTRANSMEM: Helical; Name=6 => ECO:0000255
ChainResidueDetails
BPHE792-GLN813

site_idSWS_FT_FI9
Number of Residues24
DetailsTRANSMEM: Helical; Name=7 => ECO:0000255
ChainResidueDetails
BMET829-GLU853

site_idSWS_FT_FI10
Number of Residues5
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
BSER162
BALA183
BLYS233
BGLY317
BPHE410

site_idSWS_FT_FI11
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
BLEU101
BALA461
BASN489
BGLY575
AASN547

site_idSWS_FT_FI12
Number of Residues1
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P26883
ChainResidueDetails
ALYS880

Catalytic Information from CSA
site_idMCSA1
Number of Residues6
DetailsM-CSA 362
ChainResidueDetails
ATYR854electrostatic destabiliser, steric role
APHE864electrostatic destabiliser, polar/non-polar interaction, steric role
AASP865electrostatic stabiliser, steric role
AILE884electrostatic stabiliser, steric role
ATYR910electrostatic stabiliser, steric role
APHE927electrostatic destabiliser, polar/non-polar interaction, steric role

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PDB entries from 2024-07-24

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