7EPB

Cryo-EM structure of LY354740-bound mGlu2 homodimer

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Metabotropic glutamate receptor 2	polymer	851	94061.4	2	UniProt (Q14416) Pfam (PF01094) Pfam (PF07562) Pfam (PF00003)	Homo sapiens (Human)	mGluR2
2	C, D (C, D)	Anti-RON nanobody	polymer	137	15207.9	2		Lama glama
3	E, F (A, B)	(1S,2S,5R,6S)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid	non-polymer		185.2	2	Chemie (40F)

Sequence modifications

A, B: 19 - 825 (UniProt: Q14416)

PDB	External Database	Details
Asp 9	-	expression tag
Tyr 10	-	expression tag
Lys 11	-	expression tag
Asp 12	-	expression tag
Asp 13	-	expression tag
Asp 14	-	expression tag
Asp 15	-	expression tag
Gly 16	-	expression tag
Ala 17	-	expression tag
Pro 18	-	expression tag
Ala 601	Ser 601	engineered mutation
Glu 826	-	expression tag
Phe 827	-	expression tag
Leu 828	-	expression tag
Glu 829	-	expression tag
Val 830	-	expression tag
Leu 831	-	expression tag
Phe 832	-	expression tag
Gln 833	-	expression tag
Gly 834	-	expression tag
Pro 835	-	expression tag
Gly 836	-	expression tag
Ser 837	-	expression tag
Gly 838	-	expression tag
Ser 839	-	expression tag
Trp 840	-	expression tag
Ser 841	-	expression tag
His 842	-	expression tag
Pro 843	-	expression tag
Gln 844	-	expression tag
Phe 845	-	expression tag
Glu 846	-	expression tag
Lys 847	-	expression tag
Gly 848	-	expression tag
Ser 849	-	expression tag
Gly 850	-	expression tag
Ser 851	-	expression tag
Trp 852	-	expression tag
Ser 853	-	expression tag
His 854	-	expression tag
Pro 855	-	expression tag
Gln 856	-	expression tag
Phe 857	-	expression tag
Glu 858	-	expression tag
Lys 859	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	218538.6
Non-Polymers*	Number of molecules	2
	Total formula weight	370.4
All*	Total formula weight	218909.0

*Water molecules are not included.