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7EPB

Cryo-EM structure of LY354740-bound mGlu2 homodimer

Functional Information from GO Data
ChainGOidnamespacecontents
A0001641molecular_functiongroup II metabotropic glutamate receptor activity
A0004930molecular_functionG protein-coupled receptor activity
A0005246molecular_functioncalcium channel regulator activity
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
A0007194biological_processnegative regulation of adenylate cyclase activity
A0007196biological_processadenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway
A0007215biological_processglutamate receptor signaling pathway
A0007216biological_processG protein-coupled glutamate receptor signaling pathway
A0007268biological_processchemical synaptic transmission
A0008066molecular_functionglutamate receptor activity
A0010467biological_processgene expression
A0014047biological_processglutamate secretion
A0014048biological_processregulation of glutamate secretion
A0014059biological_processregulation of dopamine secretion
A0016020cellular_componentmembrane
A0030424cellular_componentaxon
A0030425cellular_componentdendrite
A0033554biological_processcellular response to stress
A0035095biological_processbehavioral response to nicotine
A0042220biological_processresponse to cocaine
A0042734cellular_componentpresynaptic membrane
A0042995cellular_componentcell projection
A0043005cellular_componentneuron projection
A0045202cellular_componentsynapse
A0045211cellular_componentpostsynaptic membrane
A0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0051966biological_processregulation of synaptic transmission, glutamatergic
A0060292biological_processlong-term synaptic depression
A0090461biological_processintracellular glutamate homeostasis
A0097110molecular_functionscaffold protein binding
A0097449cellular_componentastrocyte projection
A0098978cellular_componentglutamatergic synapse
A0099171biological_processpresynaptic modulation of chemical synaptic transmission
A2001023biological_processregulation of response to drug
B0001641molecular_functiongroup II metabotropic glutamate receptor activity
B0004930molecular_functionG protein-coupled receptor activity
B0005246molecular_functioncalcium channel regulator activity
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
B0007194biological_processnegative regulation of adenylate cyclase activity
B0007196biological_processadenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway
B0007215biological_processglutamate receptor signaling pathway
B0007216biological_processG protein-coupled glutamate receptor signaling pathway
B0007268biological_processchemical synaptic transmission
B0008066molecular_functionglutamate receptor activity
B0010467biological_processgene expression
B0014047biological_processglutamate secretion
B0014048biological_processregulation of glutamate secretion
B0014059biological_processregulation of dopamine secretion
B0016020cellular_componentmembrane
B0030424cellular_componentaxon
B0030425cellular_componentdendrite
B0033554biological_processcellular response to stress
B0035095biological_processbehavioral response to nicotine
B0042220biological_processresponse to cocaine
B0042734cellular_componentpresynaptic membrane
B0042995cellular_componentcell projection
B0043005cellular_componentneuron projection
B0045202cellular_componentsynapse
B0045211cellular_componentpostsynaptic membrane
B0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B0051966biological_processregulation of synaptic transmission, glutamatergic
B0060292biological_processlong-term synaptic depression
B0090461biological_processintracellular glutamate homeostasis
B0097110molecular_functionscaffold protein binding
B0097449cellular_componentastrocyte projection
B0098978cellular_componentglutamatergic synapse
B0099171biological_processpresynaptic modulation of chemical synaptic transmission
B2001023biological_processregulation of response to drug
Functional Information from PROSITE/UniProt
site_idPS00979
Number of Residues19
DetailsG_PROTEIN_RECEP_F3_1 G-protein coupled receptors family 3 signature 1. VaNLLrLFqIPQISyASTS
ChainResidueDetails
AVAL151-SER169

site_idPS00980
Number of Residues23
DetailsG_PROTEIN_RECEP_F3_2 G-protein coupled receptors family 3 signature 2. CCWlCipCqpyeYrl...DefTCadC
ChainResidueDetails
ACYS518-CYS540

site_idPS00981
Number of Residues11
DetailsG_PROTEIN_RECEP_F3_3 G-protein coupled receptors family 3 signature 3. FNEAKfIGFTM
ChainResidueDetails
APHE756-MET766

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues44
DetailsTransmembrane: {"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues50
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues86
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues36
DetailsTransmembrane: {"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues42
DetailsTransmembrane: {"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues44
DetailsTransmembrane: {"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues16
DetailsRegion: {"description":"Important for interaction with HTR2A"}
ChainResidueDetails

site_idSWS_FT_FI10
Number of Residues14
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"26313429","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI11
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"26313429","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI12
Number of Residues6
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

239492

PDB entries from 2025-07-30

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