7EO5
Crystal structure of pyrano 1,3, oxazine derivative in complex with the second bromodomain of BRD2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Bromodomain-containing protein 2 | polymer | 115 | 13406.3 | 1 | UniProt (P25440) Pfam (PF00439) In PDB | Homo sapiens (Human) | O27.1.1,Really interesting new gene 3 protein |
| 2 | A | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 1 | Chemie (PGE) | |||
| 3 | A | 7-chloranyl-2-[(3-chlorophenyl)amino]pyrano[3,4-e][1,3]oxazine-4,5-dione | non-polymer | 325.1 | 1 | Chemie (BUX) | |||
| 4 | water | water | 18.0 | 132 | Chemie (HOH) |
Sequence modifications
A: 348 - 455 (UniProt: P25440)
| PDB | External Database | Details |
|---|---|---|
| Ala 341 | - | expression tag |
| Ala 342 | - | expression tag |
| His 343 | - | expression tag |
| Gly 344 | - | expression tag |
| Ser 345 | - | expression tag |
| Asn 346 | - | expression tag |
| Pro 347 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 13406.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 475.3 | |
| All* | Total formula weight | 13881.6 |
