7EM4
Crystal structure of the PI5P4Kbeta F205L-ITP complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta | polymer | 393 | 44894.9 | 2 | UniProt (P78356) Pfam (PF01504) | Homo sapiens (Human) | 1-phosphatidylinositol 5-phosphate 4-kinase 2-beta,Diphosphoinositide kinase 2-beta,Phosphatidylinositol 5-phosphate 4-kinase type II beta,PI(5)P 4-kinase type II beta,PIP4KII-beta,PtdIns(5)P-4-kinase isoform 2-beta |
| 2 | C, E (A, B) | INOSINE-5'-DIPHOSPHATE | non-polymer | 428.2 | 2 | Chemie (IDP) PubChem (136053441) PubChem (135398651) PubChem (135402347) PubChem (135450593) PubChem (135887991) PubChem (136183346) PubChem (136269906) PubChem (136364699) PubChem (136706925) PubChem (136706926) PubChem (136706927) PubChem (137031712) PubChem (137083597) PubChem (137137131) PubChem (137256750) PubChem (162468660) PubChem (166055571) PubChem (173972243) | |||
| 3 | D (A) | [[(2~{R},3~{S},4~{R},5~{R})-3,4-bis(oxidanyl)-5-(6-oxidanylidene-1~{H}-purin-9-yl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate | non-polymer | 508.2 | 1 | Chemie (CZU) PubChem (135475338) PubChem (135699675) PubChem (137247150) PubChem (135398643) PubChem (135402038) PubChem (135870597) PubChem (135887989) PubChem (135887990) PubChem (135976326) PubChem (136053443) PubChem (136162270) PubChem (136401383) PubChem (136401386) PubChem (136401388) PubChem (136663953) PubChem (136664746) PubChem (136826005) PubChem (137090202) PubChem (138454309) PubChem (163603984) PubChem (171699531) | |||
| 4 | F (A) | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
A, B: 31 - 416 (UniProt: P78356)
| PDB | External Database | Details |
|---|---|---|
| Gly 24 | - | expression tag |
| Pro 25 | - | expression tag |
| Asn 26 | - | expression tag |
| Cys 27 | - | expression tag |
| Ala 28 | - | expression tag |
| Pro 29 | - | expression tag |
| Gly 30 | - | expression tag |
| Leu 205 | Phe 205 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 89789.8 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1364.5 | |
| All* | Total formula weight | 91154.3 |
