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7EIZ

Coupling of N7-methyltransferase and 3'-5' exoribonuclease with SARS-CoV-2 polymerase reveals mechanisms for capping and proofreading

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
RNA-directed RNA polymerasepolymer929106440.61UniProt (P0DTD1)
Pfam (PF06478)
Pfam (PF00680)
Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2)Pol,RdRp,Non-structural protein 12,nsp12
2B, D
(B, D)
Non-structural protein 8polymer19821903.02UniProt (P0DTD1)
Pfam (PF08717)
Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2)nsp8
3C
(C)
Non-structural protein 7polymer839248.81UniProt (P0DTC1)
Pfam (PF08716)
Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)nsp7
4E
(G)
Non-structural protein 9polymer11312391.21UniProt (P0DTD1)
Pfam (PF08710)
Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2)nsp9
5F
(H)
Non-structural protein 10polymer13914802.91UniProt (P0DTD1)
Pfam (PF09401)
Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2)nsp10,Growth factor-like peptide,GFL
6G
(I)
primerpolymer258172.91Severe acute respiratory syndrome coronavirus 2
7H
(J)
templatepolymer278522.11Severe acute respiratory syndrome coronavirus 2
8I
(K)
Proofreading exoribonucleasepolymer52759887.51UniProt (P0DTD1)
Pfam (PF06471)
Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2)ExoN,Guanine-N7 methyltransferase,Non-structural protein 14,nsp14
9J, K
(E, F)
Helicasepolymer60166930.52UniProt (P0DTD1)
Pfam (PF20632)
Pfam (PF20633)
Pfam (PF20631)
Pfam (PF13087)
Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)Hel, Non-structural protein 13, nsp13
10L, M, N, O, P...
(A, H, K, E, F)
ZINC IONnon-polymer65.413Chemie (ZN)
11S
(K)
MAGNESIUM IONnon-polymer24.31Chemie (MG)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains11
Total formula weight397133.1
Non-Polymers*Number of molecules14
Total formula weight874.6
All*Total formula weight398007.7
*Water molecules are not included.

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PDB entries from 2025-06-11

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