7EIZ

Coupling of N7-methyltransferase and 3'-5' exoribonuclease with SARS-CoV-2 polymerase reveals mechanisms for capping and proofreading

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0003968	molecular_function	RNA-directed RNA polymerase activity
A	0005524	molecular_function	ATP binding
A	0006351	biological_process	DNA-templated transcription
A	0039694	biological_process	viral RNA genome replication
B	0004197	molecular_function	cysteine-type endopeptidase activity
B	0008242	molecular_function	omega peptidase activity
B	0016740	molecular_function	transferase activity
C	0004197	molecular_function	cysteine-type endopeptidase activity
C	0008242	molecular_function	omega peptidase activity
C	0016740	molecular_function	transferase activity
D	0004197	molecular_function	cysteine-type endopeptidase activity
D	0008242	molecular_function	omega peptidase activity
D	0016740	molecular_function	transferase activity
E	0004386	molecular_function	helicase activity
E	0005524	molecular_function	ATP binding
E	0008270	molecular_function	zinc ion binding
F	0004386	molecular_function	helicase activity
F	0005524	molecular_function	ATP binding
F	0008270	molecular_function	zinc ion binding
G	0003723	molecular_function	RNA binding
G	0019079	biological_process	viral genome replication
H	0003723	molecular_function	RNA binding
H	0008270	molecular_function	zinc ion binding
H	0019079	biological_process	viral genome replication
K	0000175	molecular_function	3'-5'-RNA exonuclease activity
K	0004482	molecular_function	mRNA 5'-cap (guanine-N7-)-methyltransferase activity
K	0004532	molecular_function	RNA exonuclease activity
K	0008168	molecular_function	methyltransferase activity

Functional Information from PROSITE/UniProt

site_id	PS00213
Number of Residues	12
Details	LIPOCALIN Lipocalin signature. GTS..KFYGGWHNM

Chain	Residue	Details
A	GLY590-MET601

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00986, ECO:0000269|PubMed:33232691, ECO:0007744|PDB:7CYQ

Chain	Residue	Details
E	CYS5
E	CYS55
E	CYS72
E	HIS75
F	CYS5
F	CYS8
F	CYS16
F	CYS19
F	CYS26
F	CYS29
F	HIS33
E	CYS8
F	HIS39
F	CYS50
F	CYS55
F	CYS72
F	HIS75
E	CYS16
E	CYS19
E	CYS26
E	CYS29
E	HIS33
E	HIS39
E	CYS50

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00990

Chain	Residue	Details
E	GLY282
K	HIS264
K	HIS268
K	ASP273
K	CYS279
K	CYS452
K	CYS477
K	CYS484
K	HIS487
F	GLY282
K	GLU191
K	CYS207
K	CYS210
K	CYS226
K	HIS229
K	HIS257
K	CYS261

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site_id	SWS_FT_FI3
Number of Residues	2
Details	SITE: Cleavage; by 3CL-PRO => ECO:0000250|UniProtKB:P0C6V3

Chain	Residue	Details
E	GLN601
F	GLN601
A	CYS306
A	CYS310

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site_id	SWS_FT_FI4
Number of Residues	1
Details	SITE: Cleavage; by 3CL-PRO => ECO:0000250|UniProtKB:P0C6V3

Chain	Residue	Details
K	GLN527
A	HIS642
A	CYS646

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site_id	SWS_FT_FI5
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01293, ECO:0000269|PubMed:32358203, ECO:0000269|PubMed:32526208, ECO:0000269|PubMed:33232691

Chain	Residue	Details
A	CYS645

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