Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7EIZ

Coupling of N7-methyltransferase and 3'-5' exoribonuclease with SARS-CoV-2 polymerase reveals mechanisms for capping and proofreading

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0003968	molecular_function	RNA-directed RNA polymerase activity
A	0005524	molecular_function	ATP binding
A	0006351	biological_process	DNA-templated transcription
A	0039694	biological_process	viral RNA genome replication
B	0004197	molecular_function	cysteine-type endopeptidase activity
B	0008242	molecular_function	omega peptidase activity
B	0016740	molecular_function	transferase activity
C	0004197	molecular_function	cysteine-type endopeptidase activity
C	0008242	molecular_function	omega peptidase activity
C	0016740	molecular_function	transferase activity
D	0004197	molecular_function	cysteine-type endopeptidase activity
D	0008242	molecular_function	omega peptidase activity
D	0016740	molecular_function	transferase activity
E	0004386	molecular_function	helicase activity
E	0005524	molecular_function	ATP binding
E	0008270	molecular_function	zinc ion binding
F	0004386	molecular_function	helicase activity
F	0005524	molecular_function	ATP binding
F	0008270	molecular_function	zinc ion binding
G	0003723	molecular_function	RNA binding
G	0019079	biological_process	viral genome replication
H	0003723	molecular_function	RNA binding
H	0008270	molecular_function	zinc ion binding
H	0019079	biological_process	viral genome replication
K	0000175	molecular_function	3'-5'-RNA exonuclease activity
K	0004482	molecular_function	mRNA 5'-cap (guanine-N7-)-methyltransferase activity
K	0004532	molecular_function	RNA exonuclease activity
K	0008168	molecular_function	methyltransferase activity

Functional Information from PROSITE/UniProt

site_id	PS00213
Number of Residues	12
Details	LIPOCALIN Lipocalin signature. GTS..KFYGGWHNM

Chain	Residue	Details
A	GLY590-MET601

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	254
Details	Domain: {"description":"NiRAN","evidences":[{"source":"PROSITE-ProRule","id":"PRU01292","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	25
Details	Repeat: {"description":"LRR 7","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	98
Details	Domain: {"description":"Nsp12 Interface","evidences":[{"source":"PROSITE-ProRule","id":"PRU01344","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	162
Details	Domain: {"description":"RdRp catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU00539","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	214
Details	Region: {"description":"RdRp Fingers N-ter","evidences":[{"source":"PROSITE-ProRule","id":"PRU01293","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	10
Details	Region: {"description":"Interaction with RMP Remdesivir","evidences":[{"source":"PubMed","id":"32358203","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	38
Details	Region: {"description":"RdRp Palm N-ter","evidences":[{"source":"PROSITE-ProRule","id":"PRU01293","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	58
Details	Region: {"description":"RdRp Fingers C-ter","evidences":[{"source":"PROSITE-ProRule","id":"PRU01293","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	135
Details	Region: {"description":"RdRp Palm C-ter","evidences":[{"source":"PROSITE-ProRule","id":"PRU01293","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	3
Details	Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01293","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33232691","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CYQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01344","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"32358203","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32526208","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33232691","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CYQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01293","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"32358203","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32526208","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33232691","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CYQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01293","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"32358203","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32526208","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33232691","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	54
Details	Repeat: {"description":"LRR 6","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	112
Details	Domain: {"description":"Nsp9 ssRNA-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU01296","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01297","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	215
Details	Domain: {"description":"ExoN","evidences":[{"source":"PROSITE-ProRule","id":"PRU01298","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	14
Details	Region: {"description":"GpppA-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU01299","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	5
Details	Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01298","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	17
Details	Binding site: {"evidences":[{"source":"PubMed","id":"36546776","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01299","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	40
Details	Repeat: {"description":"LRR 8","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI24
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00986","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"33232691","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CYQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI25
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00990","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI26
Number of Residues	112
Details	Domain: {"description":"CV ZBD","evidences":[{"source":"PROSITE-ProRule","id":"PRU00986","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI27
Number of Residues	181
Details	Domain: {"description":"(+)RNA virus helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00990","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)