7EEU
Human p53 core domain with hot spot mutation R282W in complex with the natural CDKN1A(p21) p53-response element and Arsenic
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Cellular tumor antigen p53 | polymer | 200 | 22534.6 | 8 | UniProt (P04637) Pfam (PF00870) | Homo sapiens (Human) | Antigen NY-CO-13,Phosphoprotein p53,Tumor suppressor p53 |
| 2 | I, K (I, K) | CDKN1A(p21) sense strand | polymer | 30 | 9233.0 | 2 | Homo sapiens | ||
| 3 | J, L (J, L) | CDKN1A(p21) anti-sense strand | polymer | 30 | 9214.9 | 2 | Homo sapiens | ||
| 4 | AA, CA, M, O, Q... (G, H, A, B, C...) | ARSENIC | non-polymer | 74.9 | 8 | Chemie (ARS) | |||
| 5 | BA, DA, N, P, R... (G, H, A, B, C...) | ZINC ION | non-polymer | 65.4 | 8 | Chemie (ZN) | |||
| 6 | W, Z (E, F) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 2 | Chemie (PEG) | |||
| 7 | EA, FA, GA, HA, IA... (A, B, C, D, E...) | water | water | 18.0 | 16 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H: 94 - 293 (UniProt: P04637)
| PDB | External Database | Details |
|---|---|---|
| Trp 282 | Arg 282 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 217172.5 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 1334.9 | |
| All* | Total formula weight | 218507.4 |
