7EEU
Human p53 core domain with hot spot mutation R282W in complex with the natural CDKN1A(p21) p53-response element and Arsenic
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000976 | molecular_function | transcription cis-regulatory region binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0006915 | biological_process | apoptotic process |
| B | 0000976 | molecular_function | transcription cis-regulatory region binding |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0006915 | biological_process | apoptotic process |
| C | 0000976 | molecular_function | transcription cis-regulatory region binding |
| C | 0003677 | molecular_function | DNA binding |
| C | 0003700 | molecular_function | DNA-binding transcription factor activity |
| C | 0005634 | cellular_component | nucleus |
| C | 0006355 | biological_process | regulation of DNA-templated transcription |
| C | 0006915 | biological_process | apoptotic process |
| D | 0000976 | molecular_function | transcription cis-regulatory region binding |
| D | 0003677 | molecular_function | DNA binding |
| D | 0003700 | molecular_function | DNA-binding transcription factor activity |
| D | 0005634 | cellular_component | nucleus |
| D | 0006355 | biological_process | regulation of DNA-templated transcription |
| D | 0006915 | biological_process | apoptotic process |
| E | 0000976 | molecular_function | transcription cis-regulatory region binding |
| E | 0003677 | molecular_function | DNA binding |
| E | 0003700 | molecular_function | DNA-binding transcription factor activity |
| E | 0005634 | cellular_component | nucleus |
| E | 0006355 | biological_process | regulation of DNA-templated transcription |
| E | 0006915 | biological_process | apoptotic process |
| F | 0000976 | molecular_function | transcription cis-regulatory region binding |
| F | 0003677 | molecular_function | DNA binding |
| F | 0003700 | molecular_function | DNA-binding transcription factor activity |
| F | 0005634 | cellular_component | nucleus |
| F | 0006355 | biological_process | regulation of DNA-templated transcription |
| F | 0006915 | biological_process | apoptotic process |
| G | 0000976 | molecular_function | transcription cis-regulatory region binding |
| G | 0003677 | molecular_function | DNA binding |
| G | 0003700 | molecular_function | DNA-binding transcription factor activity |
| G | 0005634 | cellular_component | nucleus |
| G | 0006355 | biological_process | regulation of DNA-templated transcription |
| G | 0006915 | biological_process | apoptotic process |
| H | 0000976 | molecular_function | transcription cis-regulatory region binding |
| H | 0003677 | molecular_function | DNA binding |
| H | 0003700 | molecular_function | DNA-binding transcription factor activity |
| H | 0005634 | cellular_component | nucleus |
| H | 0006355 | biological_process | regulation of DNA-templated transcription |
| H | 0006915 | biological_process | apoptotic process |
Functional Information from PROSITE/UniProt
| site_id | PS00348 |
| Number of Residues | 13 |
| Details | P53 p53 family signature. MCNSSCMGGMNRR |
| Chain | Residue | Details |
| A | MET237-ARG249 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1520 |
| Details | DNA_BIND: DNA_BIND => ECO:0000269|PubMed:16793544, ECO:0000269|PubMed:18996393, ECO:0000269|PubMed:20364130 |
| Chain | Residue | Details |
| A | THR102-LYS292 | |
| B | THR102-LYS292 | |
| C | THR102-LYS292 | |
| D | THR102-LYS292 | |
| E | THR102-LYS292 | |
| F | THR102-LYS292 | |
| G | THR102-LYS292 | |
| H | THR102-LYS292 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 32 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:14534297, ECO:0000269|PubMed:16793544, ECO:0000269|PubMed:17015838, ECO:0000269|PubMed:18650397, ECO:0000269|PubMed:19515728, ECO:0000269|PubMed:20142040, ECO:0000269|PubMed:20364130 |
| Chain | Residue | Details |
| A | CYS176 | |
| C | HIS179 | |
| C | CYS238 | |
| C | CYS242 | |
| D | CYS176 | |
| D | HIS179 | |
| D | CYS238 | |
| D | CYS242 | |
| E | CYS176 | |
| E | HIS179 | |
| E | CYS238 | |
| A | HIS179 | |
| E | CYS242 | |
| F | CYS176 | |
| F | HIS179 | |
| F | CYS238 | |
| F | CYS242 | |
| G | CYS176 | |
| G | HIS179 | |
| G | CYS238 | |
| G | CYS242 | |
| H | CYS176 | |
| A | CYS238 | |
| H | HIS179 | |
| H | CYS238 | |
| H | CYS242 | |
| A | CYS242 | |
| B | CYS176 | |
| B | HIS179 | |
| B | CYS238 | |
| B | CYS242 | |
| C | CYS176 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | SITE: Interaction with DNA => ECO:0000269|PubMed:16793544, ECO:0000269|PubMed:18996393, ECO:0000269|PubMed:20364130 |
| Chain | Residue | Details |
| A | LYS120 | |
| B | LYS120 | |
| C | LYS120 | |
| D | LYS120 | |
| E | LYS120 | |
| F | LYS120 | |
| G | LYS120 | |
| H | LYS120 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:17189187, ECO:0000269|PubMed:19854137, ECO:0000269|PubMed:23431171 |
| Chain | Residue | Details |
| A | LYS120 | |
| B | LYS120 | |
| C | LYS120 | |
| D | LYS120 | |
| E | LYS120 | |
| F | LYS120 | |
| G | LYS120 | |
| H | LYS120 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 16 |
| Details | MOD_RES: Phosphoserine; by AURKB => ECO:0000269|PubMed:20959462 |
| Chain | Residue | Details |
| A | SER183 | |
| E | SER269 | |
| F | SER183 | |
| F | SER269 | |
| G | SER183 | |
| G | SER269 | |
| H | SER183 | |
| H | SER269 | |
| A | SER269 | |
| B | SER183 | |
| B | SER269 | |
| C | SER183 | |
| C | SER269 | |
| D | SER183 | |
| D | SER269 | |
| E | SER183 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphothreonine; by AURKB => ECO:0000269|PubMed:20959462 |
| Chain | Residue | Details |
| A | THR284 | |
| B | THR284 | |
| C | THR284 | |
| D | THR284 | |
| E | THR284 | |
| F | THR284 | |
| G | THR284 | |
| H | THR284 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 24 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:19536131 |
| Chain | Residue | Details |
| A | LYS291 | |
| D | LYS291 | |
| D | LYS292 | |
| E | LYS291 | |
| E | LYS292 | |
| F | LYS291 | |
| F | LYS292 | |
| G | LYS291 | |
| G | LYS292 | |
| H | LYS291 | |
| H | LYS292 | |
| A | LYS292 | |
| B | LYS291 | |
| B | LYS292 | |
| C | LYS291 | |
| C | LYS292 |
