7E7B
Cryo-EM structure of the SARS-CoV-2 furin site mutant S-Trimer from a subunit vaccine candidate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Spike glycoprotein,Collagen alpha-1(I) chain | polymer | 1520 | 168078.2 | 3 | UniProt (P0DTC2) UniProt (P02452) Pfam (PF16451) Pfam (PF09408) Pfam (PF19209) Pfam (PF01601) Pfam (PF01391) Pfam (PF01410) | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2) | S glycoprotein,E2,Peplomer protein,Alpha-1 type I collagen |
| 2 | AA, BA, CA, D, DA... (a, b, c, D, d...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 39 | In PDB GlyTouCan (G42666HT) | |||
| 3 | AB, BB, CB, DB, GB... (B, C, A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 15 | Chemie (NAG) | |||
| 4 | EB, VA, WA (B, A) | 9-OCTADECENOIC ACID | non-polymer | 282.5 | 3 | Chemie (ELA) | |||
| 5 | FB, XA, YA (B, A) | 2-hydroxyethyl 2-deoxy-3,5-bis-O-(2-hydroxyethyl)-6-O-(2-{[(9E)-octadec-9-enoyl]oxy}ethyl)-alpha-L-xylo-hexofuranoside | non-polymer | 604.8 | 3 | Chemie (VCG) | |||
| 6 | LB, MB, NB (A, B, C) | water | water | 18.0 | 36 | Chemie (HOH) |
Sequence modifications
A, B, C: 1 - 1211 (UniProt: P0DTC2)
A, B, C: 1214 - 1520 (UniProt: P02452)
| PDB | External Database | Details |
|---|---|---|
| Ala 685 | Arg 685 | engineered mutation |
| Arg 1212 | - | linker |
| Ser 1213 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Asn 1277 | Asp 1219 | variant |
| Lys 1449 | Gln 1391 | variant |
| Ser 1492 | Thr 1434 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 504234.6 | |
| Branched | Number of molecules | 39 |
| Total formula weight | 16551.6 | |
| Non-Polymers* | Number of molecules | 21 |
| Total formula weight | 5979.9 | |
| All* | Total formula weight | 526766.2 |
