7E3N
Crystal structure of Isocitrate dehydrogenase D252N mutant from Trypanosoma brucei in complexed with NADP+, alpha-ketoglutarate, and ca2+
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Isocitrate dehydrogenase [NADP] | polymer | 413 | 46790.6 | 1 | UniProt (Q387G0) Pfam (PF00180) | Trypanosoma brucei brucei (strain 927/4 GUTat10.1) | |
| 2 | B (A) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 1 | Chemie (NAP) | |||
| 3 | C (A) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 4 | D (A) | ISOCITRIC ACID | non-polymer | 192.1 | 1 | Chemie (ICT) | |||
| 5 | E (A) | water | water | 18.0 | 87 | Chemie (HOH) |
Sequence modifications
A: 1 - 413 (UniProt: Q387G0)
| PDB | External Database | Details |
|---|---|---|
| Ser 1 | Met 1 | engineered mutation |
| Asn 252 | Asp 252 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 46790.6 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 975.6 | |
| All* | Total formula weight | 47766.2 |
