7DU9

Crystal structure of human Proto-oncogene tyrosine-protein kinase receptor Ret in complex with Pralsetinib

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Proto-oncogene tyrosine-protein kinase receptor Ret	polymer	314	35708.2	2	UniProt (P07949) Pfam (PF07714) In PDB	Homo sapiens (Human)	Cadherin family member 12,Proto-oncogene c-Ret
2	A, B	Pralsetinib	non-polymer		533.6	2	Chemie (Q4J)
3		water	water		18.0	172	Chemie (HOH)

Sequence modifications

A, B: 705 - 1013 (UniProt: P07949)

PDB	External Database	Details
Gly 700	-	expression tag
Pro 701	-	expression tag
Leu 702	-	expression tag
Ser 703	-	expression tag
Leu 704	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	71416.5
Non-Polymers*	Number of molecules	2
	Total formula weight	1067.2
All*	Total formula weight	72483.7

*Water molecules are not included.