7DU9
Crystal structure of human Proto-oncogene tyrosine-protein kinase receptor Ret in complex with Pralsetinib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Proto-oncogene tyrosine-protein kinase receptor Ret | polymer | 314 | 35708.2 | 2 | UniProt (P07949) Pfam (PF07714) | Homo sapiens (Human) | Cadherin family member 12,Proto-oncogene c-Ret |
| 2 | C, D (A, B) | Pralsetinib | non-polymer | 533.6 | 2 | Chemie (Q4J) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 172 | Chemie (HOH) |
Sequence modifications
A, B: 705 - 1013 (UniProt: P07949)
| PDB | External Database | Details |
|---|---|---|
| Gly 700 | - | expression tag |
| Pro 701 | - | expression tag |
| Leu 702 | - | expression tag |
| Ser 703 | - | expression tag |
| Leu 704 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 71416.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1067.2 | |
| All* | Total formula weight | 72483.7 |
