7DHA
crystal structure of CD38 in complex with daratumumab
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | polymer | 265 | 30792.9 | 1 | UniProt (P28907) Pfam (PF02267) In PDB | Homo sapiens (Human) | 2'-phospho-ADP-ribosyl cyclase,2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase,2'-phospho-cyclic-ADP-ribose transferase,ADP-ribosyl cyclase 1,ADPRC 1,Cyclic ADP-ribose hydrolase 1,cADPr hydrolase 1,T10 |
2 | B | Light chain | polymer | 214 | 23405.9 | 1 | Homo sapiens | ||
3 | C | Heavy Chain | polymer | 234 | 24932.0 | 1 | Homo sapiens | ||
4 | water | water | 18.0 | 143 | Chemie (HOH) |
Sequence modifications
A: 1 - 256 (UniProt: P28907)
PDB | External Database | Details |
---|---|---|
Asp 56 | Asn 100 | engineered mutation |
Ala 120 | Asn 164 | engineered mutation |
Asp 165 | Asn 209 | engineered mutation |
Asp 175 | Asn 219 | engineered mutation |
Gly 257 | - | expression tag |
Thr 258 | - | expression tag |
Lys 259 | - | expression tag |
His 260 | - | expression tag |
His 261 | - | expression tag |
His 262 | - | expression tag |
His 263 | - | expression tag |
His 264 | - | expression tag |
His 265 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 79130.8 | |
All* | Total formula weight | 79130.8 |