7DHA

crystal structure of CD38 in complex with daratumumab

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1	polymer	265	30792.9	1	UniProt (P28907) Pfam (PF02267)	Homo sapiens (Human)	2'-phospho-ADP-ribosyl cyclase,2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase,2'-phospho-cyclic-ADP-ribose transferase,ADP-ribosyl cyclase 1,ADPRC 1,Cyclic ADP-ribose hydrolase 1,cADPr hydrolase 1,T10
2	B (B)	Light chain	polymer	214	23405.9	1		Homo sapiens
3	C (C)	Heavy Chain	polymer	234	24932.0	1		Homo sapiens
4	D, E, F (A, B, C)	water	water		18.0	143	Chemie (HOH)

Sequence modifications

A: 1 - 256 (UniProt: P28907)

PDB	External Database	Details
Asp 56	Asn 100	engineered mutation
Ala 120	Asn 164	engineered mutation
Asp 165	Asn 209	engineered mutation
Asp 175	Asn 219	engineered mutation
Gly 257	-	expression tag
Thr 258	-	expression tag
Lys 259	-	expression tag
His 260	-	expression tag
His 261	-	expression tag
His 262	-	expression tag
His 263	-	expression tag
His 264	-	expression tag
His 265	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	79130.8
All*	Total formula weight	79130.8

*Water molecules are not included.