7DH0
Activity optimized complex I (open form)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (2) | NADH-ubiquinone oxidoreductase chain 2 | polymer | 347 | 39274.9 | 1 | UniProt (P03892) Pfam (PF00361) Pfam (PF06444) | Bos taurus (Bovine) | NADH dehydrogenase subunit 2 |
| 2 | B (3) | NADH-ubiquinone oxidoreductase chain 3 | polymer | 115 | 13058.5 | 1 | UniProt (P03898) Pfam (PF00507) | Bos taurus (Bovine) | NADH dehydrogenase subunit 3 |
| 3 | C (4) | NADH-ubiquinone oxidoreductase chain 4 | polymer | 459 | 52130.8 | 1 | UniProt (P03910) Pfam (PF01059) Pfam (PF00361) | Bos taurus (Bovine) | NADH dehydrogenase subunit 4 |
| 4 | D (5) | NADH-ubiquinone oxidoreductase chain 4L | polymer | 98 | 10800.2 | 1 | UniProt (P03902) Pfam (PF00420) | Bos taurus (Bovine) | NADH dehydrogenase subunit 4L |
| 5 | E (7) | NADH-ubiquinone oxidoreductase chain 6 | polymer | 175 | 19082.5 | 1 | UniProt (P03924) Pfam (PF00499) | Bos taurus (Bovine) | NADH dehydrogenase subunit 6 |
| 6 | F (8) | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial | polymer | 444 | 48562.1 | 1 | UniProt (P25708) Pfam (PF01512) Pfam (PF22461) Pfam (PF10589) | Bos taurus (Bovine) | Complex I-51kD,CI-51kD,NADH dehydrogenase flavoprotein 1,NADH-ubiquinone oxidoreductase 51 kDa subunit |
| 7 | G (9) | NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial | polymer | 217 | 23840.4 | 1 | UniProt (P04394) Pfam (PF01257) | Bos taurus (Bovine) | NADH dehydrogenase subunit II,NADH-ubiquinone oxidoreductase 24 kDa subunit |
| 8 | H (A) | NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial | polymer | 704 | 77044.1 | 1 | UniProt (P15690) Pfam (PF00111) Pfam (PF10588) Pfam (PF22117) Pfam (PF22151) Pfam (PF00384) Pfam (PF09326) | Bos taurus (Bovine) | Complex I-75kD,CI-75kD |
| 9 | I (B) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial | polymer | 430 | 49207.3 | 1 | UniProt (P17694) Pfam (PF00346) | Bos taurus (Bovine) | Complex I-49kD,CI-49kD,NADH-ubiquinone oxidoreductase 49 kDa subunit |
| 10 | J (C) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial | polymer | 228 | 26464.8 | 1 | UniProt (P23709) Pfam (PF00329) | Bos taurus (Bovine) | Complex I-30kD,CI-30kD,NADH-ubiquinone oxidoreductase 30 kDa subunit |
| 11 | K (D) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial | polymer | 179 | 20104.5 | 1 | UniProt (P42026) Pfam (PF01058) | Bos taurus (Bovine) | Complex I-20kD,CI-20kD,NADH-ubiquinone oxidoreductase 20 kDa subunit,PSST subunit |
| 12 | L (E) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial | polymer | 176 | 20219.9 | 1 | UniProt (P42028) Pfam (PF12838) | Bos taurus (Bovine) | Complex I-23kD,CI-23kD,NADH-ubiquinone oxidoreductase 23 kDa subunit,TYKY subunit |
| 13 | M (F) | NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial | polymer | 75 | 8451.4 | 1 | UniProt (P25712) Pfam (PF15880) | Bos taurus (Bovine) | Complex I-9kD,CI-9kD,NADH-ubiquinone oxidoreductase 9 kDa subunit |
| 14 | N (G) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial | polymer | 133 | 15361.3 | 1 | UniProt (Q02375) Pfam (PF04800) | Bos taurus (Bovine) | Complex I-18 kDa,CI-18 kDa,Complex I-AQDQ,CI-AQDQ,NADH-ubiquinone oxidoreductase 18 kDa subunit |
| 15 | O (H) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 | polymer | 105 | 12563.5 | 1 | UniProt (Q02379) Pfam (PF10200) | Bos taurus (Bovine) | Complex I-15 kDa,CI-15 kDa,NADH-ubiquinone oxidoreductase 15 kDa subunit |
| 16 | P (I) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial | polymer | 96 | 10551.7 | 1 | UniProt (P23934) Pfam (PF10276) | Bos taurus (Bovine) | Complex I-13kD-A,CI-13kD-A,NADH-ubiquinone oxidoreductase 13 kDa-A subunit |
| 17 | Q (J) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 | polymer | 70 | 8117.4 | 1 | UniProt (Q02377) Pfam (PF15879) | Bos taurus (Bovine) | Complex I-MWFE,CI-MWFE,NADH-ubiquinone oxidoreductase MWFE subunit |
| 18 | R (K) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 | polymer | 98 | 10966.6 | 1 | UniProt (Q02370) Pfam (PF05047) | Bos taurus (Bovine) | Complex I-B8,CI-B8,NADH-ubiquinone oxidoreductase B8 subunit |
| 19 | S (L) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 | polymer | 83 | 9226.7 | 1 | UniProt (Q02371) Pfam (PF14987) | Bos taurus (Bovine) | Complex I-B9,CI-B9,NADH-ubiquinone oxidoreductase B9 subunit |
| 20 | T (N) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 | polymer | 115 | 13203.4 | 1 | UniProt (P23935) Pfam (PF04716) | Bos taurus (Bovine) | Complex I subunit B13,Complex I-13kD-B,CI-13kD-B,NADH-ubiquinone oxidoreductase 13 kDa-B subunit |
| 21 | U (O) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 | polymer | 127 | 14952.3 | 1 | UniProt (Q02366) Pfam (PF13233) | Bos taurus (Bovine) | Complex I-B14,CI-B14,NADH-ubiquinone oxidoreductase B14 subunit |
| 22 | V (P) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 | polymer | 112 | 12564.4 | 1 | UniProt (Q05752) Pfam (PF07347) | Bos taurus (Bovine) | Complex I-B14.5a,CI-B14.5a,NADH-ubiquinone oxidoreductase subunit B14.5a |
| 23 | W (Q) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 | polymer | 171 | 19992.9 | 1 | UniProt (P42029) Pfam (PF06747) | Bos taurus (Bovine) | Complex I-19kD,CI-19kD,Complex I-PGIV,CI-PGIV,NADH-ubiquinone oxidoreductase 19 kDa subunit |
| 24 | X (R) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial | polymer | 345 | 39174.0 | 1 | UniProt (P34943) Pfam (PF01370) | Bos taurus (Bovine) | Complex I-39kD,CI-39kD,NADH-ubiquinone oxidoreductase 39 kDa subunit |
| 25 | Y (S) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial | polymer | 320 | 36739.7 | 1 | UniProt (P34942) Pfam (PF01712) | Bos taurus (Bovine) | Complex I-42kD,CI-42kD,NADH-ubiquinone oxidoreductase 42 kDa subunit |
| 26 | Z (T) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 | polymer | 140 | 14640.8 | 1 | UniProt (Q8HXG6) Pfam (PF02466) | Bos taurus (Bovine) | Complex I-B14.7,CI-B14.7,NADH-ubiquinone oxidoreductase subunit B14.7 |
| 27 | AA (U) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 | polymer | 145 | 17115.5 | 1 | UniProt (O97725) Pfam (PF05071) | Bos taurus (Bovine) | Complex I-B17.2,CIB17.2,NADH-ubiquinone oxidoreductase subunit B17.2 |
| 28 | BA (V) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 | polymer | 143 | 16563.2 | 1 | UniProt (Q95KV7) Pfam (PF06212) | Bos taurus (Bovine) | Cell death regulatory protein GRIM-19,Complex I-B16.6,CI-B16.6,Gene associated with retinoic-interferon-induced mortality 19 protein,GRIM-19,NADH-ubiquinone oxidoreductase B16.6 subunit |
| 29 | CA, SA (W, M) | Acyl carrier protein, mitochondrial | polymer | 88 | 10119.5 | 2 | UniProt (P52505) Pfam (PF00550) | Bos taurus (Bovine) | ACP,CI-SDAP,NADH-ubiquinone oxidoreductase 9.6 kDa subunit |
| 30 | DA (X) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 | polymer | 57 | 6978.1 | 1 | UniProt (Q02378) Pfam (PF08040) | Bos taurus (Bovine) | Complex I-MNLL,CI-MNLL,NADH-ubiquinone oxidoreductase MNLL subunit |
| 31 | EA (Y) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial | polymer | 72 | 8500.3 | 1 | UniProt (Q02374) Pfam (PF14813) | Bos taurus (Bovine) | Complex I-AGGG,CI-AGGG,NADH-ubiquinone oxidoreductase AGGG subunit |
| 32 | FA (Z) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 | polymer | 97 | 11029.5 | 1 | UniProt (Q02365) Pfam (PF08122) | Bos taurus (Bovine) | Complex I-B12,CI-B12,NADH-ubiquinone oxidoreductase B12 subunit |
| 33 | GA (a) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 | polymer | 128 | 15075.1 | 1 | UniProt (P48305) Pfam (PF07225) | Bos taurus (Bovine) | Complex I-B15,CI-B15,NADH-ubiquinone oxidoreductase B15 subunit |
| 34 | HA (b) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial | polymer | 143 | 16752.4 | 1 | UniProt (Q02380) Pfam (PF09781) | Bos taurus (Bovine) | Complex I-SGDH,CI-SGDH,NADH-ubiquinone oxidoreductase SGDH subunit |
| 35 | IA (c) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 | polymer | 127 | 15418.9 | 1 | UniProt (Q02367) Pfam (PF09782) | Bos taurus (Bovine) | Complex I-B17,CI-B17,NADH-ubiquinone oxidoreductase B17 subunit |
| 36 | JA (d) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 | polymer | 136 | 16297.6 | 1 | UniProt (Q02368) Pfam (PF05676) | Bos taurus (Bovine) | Complex I-B18,CI-B18,NADH-ubiquinone oxidoreductase B18 subunit |
| 37 | KA (f) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 | polymer | 178 | 21696.7 | 1 | UniProt (Q02369) Pfam (PF05347) | Bos taurus (Bovine) | Complex I-B22,CI-B22,NADH-ubiquinone oxidoreductase B22 subunit |
| 38 | LA (h) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial | polymer | 125 | 14469.1 | 1 | UniProt (Q8HXG5) Pfam (PF10183) | Bos taurus (Bovine) | Complex I-ESSS,CI-ESSS,NADH-ubiquinone oxidoreductase ESSS subunit |
| 39 | MA (i) | NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial | polymer | 49 | 5836.7 | 1 | UniProt (Q02376) Pfam (PF15088) | Bos taurus (Bovine) | Complex I-KFYI,CI-KFYI,NADH-ubiquinone oxidoreductase KFYI subunit |
| 40 | NA (j) | NADH dehydrogenase [ubiquinone] 1 subunit C2 | polymer | 120 | 14117.3 | 1 | UniProt (Q02827) Pfam (PF06374) | Bos taurus (Bovine) | Complex I-B14.5b,CI-B14.5b,NADH-ubiquinone oxidoreductase subunit B14.5b |
| 41 | OA (1) | NADH-ubiquinone oxidoreductase chain 1 | polymer | 318 | 35688.8 | 1 | UniProt (P03887) Pfam (PF00146) | Bos taurus (Bovine) | NADH dehydrogenase subunit 1 |
| 42 | PA (6) | NADH-ubiquinone oxidoreductase chain 5 | polymer | 606 | 68327.9 | 1 | UniProt (P03920) Pfam (PF06455) Pfam (PF00662) Pfam (PF00361) | Bos taurus (Bovine) | NADH dehydrogenase subunit 5 |
| 43 | QA (g) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 | polymer | 176 | 21000.9 | 1 | UniProt (Q02373) Pfam (PF10249) | Bos taurus (Bovine) | Complex I-PDSW,CI-PDSW,NADH-ubiquinone oxidoreductase PDSW subunit |
| 44 | RA (e) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial | polymer | 158 | 18758.0 | 1 | UniProt (Q02372) Pfam (PF05821) | Bos taurus (Bovine) | Complex I-ASHI,CI-ASHI,NADH-ubiquinone oxidoreductase ASHI subunit |
| 45 | CB, TA, VA (B, 2, 4) | 1,2-Distearoyl-sn-glycerophosphoethanolamine | non-polymer | 748.1 | 3 | Chemie (3PE) | |||
| 46 | UA (4) | CARDIOLIPIN | non-polymer | 1464.0 | 1 | Chemie (CDL) | |||
| 47 | WA (8) | FLAVIN MONONUCLEOTIDE | non-polymer | 456.3 | 1 | Chemie (FMN) | |||
| 48 | AB, DB, EB, FB, XA... (A, D, E, 8) | IRON/SULFUR CLUSTER | non-polymer | 351.6 | 6 | Chemie (SF4) | |||
| 49 | BB, YA (A, 9) | FE2/S2 (INORGANIC) CLUSTER | non-polymer | 175.8 | 2 | Chemie (FES) | |||
| 50 | GB (I) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 51 | HB (R) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 1 | Chemie (NAP) | |||
| 52 | IB, JB (S, j) | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 790.1 | 2 | Chemie (PC1) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 45 |
| Total formula weight | 970161.3 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 9015.2 | |
| All* | Total formula weight | 979176.4 |
