7DFH

Structure of COVID-19 RNA-dependent RNA polymerase bound to ribavirin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	RNA-directed RNA polymeras	polymer	943	107965.3	1	UniProt (P0DTD1) Pfam (PF06478) Pfam (PF00680)	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)
2	B, D (B, G)	Non-structural protein 8	polymer	199	22034.2	2	UniProt (P0DTD1) Pfam (PF08717)	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)
3	C (C)	Non-structural protein 7	polymer	84	9380.0	1	UniProt (P0DTD1) Pfam (PF08716)	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)
4	E (P)	RNA (5'-R(P*GP*CP*UP*AP*UP*GP*UP*G*(LIG))-3')	polymer	8	2543.5	1		Severe acute respiratory syndrome coronavirus 2
5	F (T)	RNA (5'-R(P*CP*CP*CP*CP*CP*AP*CP*AP*UP*AP*GP*C)-3')	polymer	12	3730.3	1		Severe acute respiratory syndrome coronavirus 2
6	G, H (A)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
7	I, J, K (A)	MAGNESIUM ION	non-polymer		24.3	3	Chemie (MG)
8	L, M (A)	PYROPHOSPHATE 2-	non-polymer		176.0	2	Chemie (POP)
9	N (P)	RIBAVIRIN MONOPHOSPHATE	non-polymer		324.2	1	Chemie (RVP)
10	O (A)	water	water		18.0	2	Chemie (HOH)

Sequence modifications

A: 1 - 932 (UniProt: P0DTD1)

PDB	External Database	Details
Met 0	-	initiating methionine
Gly 933	-	expression tag
Gly 934	-	expression tag
Ser 935	-	expression tag
Glu 936	-	expression tag
Asn 937	-	expression tag
Leu 938	-	expression tag
Tyr 939	-	expression tag
Phe 940	-	expression tag
Gln 941	-	expression tag
Gly 942	-	expression tag

B, G: 1 - 198 (UniProt: P0DTD1)

PDB	External Database	Details
Met 0	-	initiating methionine

C: 1 - 83 (UniProt: P0DTD1)

PDB	External Database	Details
Met 0	-	initiating methionine

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	167687.6
Non-Polymers*	Number of molecules	8
	Total formula weight	879.8
All*	Total formula weight	168567.4

*Water molecules are not included.