7DFG

Structure of COVID-19 RNA-dependent RNA polymerase bound to favipiravir

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	P	RNA (5'-R(P*AP*GP*AP*UP*UP*AP*AP*GP*UP*UP*AP*U)-3')	polymer	12	3822.3	1		Severe acute respiratory syndrome coronavirus 2
2	T	RNA (5'-R(P*CP*CP*CP*UP*AP*UP*AP*AP*CP*UP*UP*AP*AP*UP*CP*U)-3')	polymer	16	4964.0	1		Severe acute respiratory syndrome coronavirus 2
3	A	RNA-directed RNA polymerase	polymer	943	107965.3	1	UniProt (P0DTD1) Pfam (PF06478) Pfam (PF00680) In PDB	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)
4	B, G	Non-structural protein 8	polymer	199	22034.2	2	UniProt (P0DTD1) Pfam (PF08717) In PDB	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)
5	C	Non-structural protein 7	polymer	84	9380.0	1	UniProt (P0DTD1) Pfam (PF08716) In PDB	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)
6	P	6-fluoro-3-oxo-4-(5-O-phosphono-beta-D-ribofuranosyl)-3,4-dihydropyrazine-2-carboxamide	non-polymer		369.2	1	Chemie (1RP)
7	A	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
8	A	PYROPHOSPHATE 2-	non-polymer		176.0	2	Chemie (POP)
9	A	MAGNESIUM ION	non-polymer		24.3	4	Chemie (MG)
10		water	water		18.0	5	Chemie (HOH)

Sequence modifications

A: 1 - 932 (UniProt: P0DTD1)

PDB	External Database	Details
Met 0	-	initiating methionine
Gly 933	-	expression tag
Gly 934	-	expression tag
Ser 935	-	expression tag
Glu 936	-	expression tag
Asn 937	-	expression tag
Leu 938	-	expression tag
Tyr 939	-	expression tag
Phe 940	-	expression tag
Gln 941	-	expression tag
Gly 942	-	expression tag

B, G: 1 - 198 (UniProt: P0DTD1)

PDB	External Database	Details
Met 0	-	initiating methionine

C: 1 - 83 (UniProt: P0DTD1)

PDB	External Database	Details
Met 0	-	initiating methionine

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	170200.0
Non-Polymers*	Number of molecules	9
	Total formula weight	949.2
All*	Total formula weight	171149.2

*Water molecules are not included.