7DDZ

The Crystal Structure of Human Neuropeptide Y Y2 Receptor with JNJ-31020028

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Human Neuropeptide Y Y2 Receptor fusion protein	polymer	665	74285.3	1	UniProt (A0A097J809) UniProt (P49146) UniProt (P00323) Pfam (PF00001) Pfam (PF00258)	Enterobacteria phage RB59	Lysis protein,Lysozyme,Muramidase,NPY2-R,NPY-Y2 receptor,Y2 receptor
2	B (A)	~{N}-[4-[4-[(1~{S})-2-(diethylamino)-2-oxidanylidene-1-phenyl-ethyl]piperazin-1-yl]-3-fluoranyl-phenyl]-2-pyridin-3-yl-benzamide	non-polymer		565.7	1	Chemie (H46)
3	C (A)	FLAVIN MONONUCLEOTIDE	non-polymer		456.3	1	Chemie (FMN)

Sequence modifications

A: -159 - 0 (UniProt: A0A097J809)

PDB	External Database	Details
Gly -162	-	expression tag
Ala -161	-	expression tag
Pro -160	-	expression tag
Thr -107	Cys 54	engineered mutation
Ala -64	Cys 97	engineered mutation

A: 1 - 250 (UniProt: P49146)

PDB	External Database	Details
Tyr 149	His 149	engineered mutation

A: 1001 - 1146 (UniProt: P00323)

PDB	External Database	Details
Trp 1096	Tyr 98	engineered mutation

A: 257 - 353 (UniProt: P49146)

PDB	External Database	Details
Ala 1000	-	linker
Cys 280	Ser 280	engineered mutation
Glu 354	-	expression tag
Phe 355	-	expression tag
Leu 356	-	expression tag
Glu 357	-	expression tag
Val 358	-	expression tag
Leu 359	-	expression tag
Phe 360	-	expression tag
Gln 361	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	74285.3
Non-Polymers*	Number of molecules	2
	Total formula weight	1022.0
All*	Total formula weight	75307.3

*Water molecules are not included.