7DCE

Cryo-EM structure of human XKR8-basigin complex bound to Fab fragment

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (B)	Isoform 2 of Basigin	polymer	176	19592.8	1	UniProt (P35613) Pfam (PF13927)	Homo sapiens (human)	5F7,Collagenase stimulatory factor,Extracellular matrix metalloproteinase inducer,EMMPRIN,Hepatoma-associated antigen,HAb18G,Leukocyte activation antigen M6,OK blood group antigen,Tumor cell-derived collagenase stimulatory factor,TCSF
2	B (X)	XK-related protein 8	polymer	405	45975.6	1	UniProt (Q9H6D3) Pfam (PF09815)	Homo sapiens (human)	hXkr8
3	C (H)	Heavy chain of Fab fragment	polymer	217	22869.6	1		Oryctolagus cuniculus (Rabbit)
4	D (L)	Light chain of Fab fragment	polymer	218	23261.9	1		Oryctolagus cuniculus (Rabbit)
5	E (X)	1,2-DILINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE	non-polymer		782.1	1	Chemie (DLP)

Sequence modifications

B: 103 - 269 (UniProt: P35613)

PDB	External Database	Details
Ala 102	-	expression tag
Gln 152	Asn 152	engineered mutation
Gln 186	Asn 186	engineered mutation
Asp 270	-	expression tag
Tyr 271	-	expression tag
Lys 272	-	expression tag
Asp 273	-	expression tag
Asp 274	-	expression tag
Asp 275	-	expression tag
Asp 276	-	expression tag
Lys 277	-	expression tag

X: 1 - 395 (UniProt: Q9H6D3)

PDB	External Database	Details
Val 396	-	expression tag
Asp 397	-	expression tag
Glu 398	-	expression tag
Phe 399	-	expression tag
Glu 400	-	expression tag
Asn 401	-	expression tag
Leu 402	-	expression tag
Tyr 403	-	expression tag
Phe 404	-	expression tag
Gln 405	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	111699.9
Non-Polymers*	Number of molecules	1
	Total formula weight	782.1
All*	Total formula weight	112482.0

*Water molecules are not included.