7DB8
Crystal structure of Mycobacterium tuberculosis phenylalanyl-tRNA synthetase in complex with compound PF-3845
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Phenylalanine--tRNA ligase alpha subunit | polymer | 341 | 37415.3 | 1 | UniProt (P9WFU3) Pfam (PF02912) Pfam (PF01409) | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) | Phenylalanyl-tRNA synthetase alpha subunit,PheRS |
| 2 | B (B) | Phenylalanine--tRNA ligase beta subunit | polymer | 845 | 90179.8 | 1 | UniProt (P9WFU1) Pfam (PF01588) Pfam (PF03483) Pfam (PF03484) Pfam (PF17759) Pfam (PF03147) | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) | Phenylalanyl-tRNA synthetase beta subunit,PheRS |
| 3 | C, D, E, G, H... (A, B) | SULFATE ION | non-polymer | 96.1 | 13 | Chemie (SO4) | |||
| 4 | F (A) | N-pyridin-3-yl-4-[[3-[5-(trifluoromethyl)pyridin-2-yl]oxyphenyl]methyl]piperidine-1-carboxamide | non-polymer | 456.5 | 1 | Chemie (H2R) | |||
| 5 | Q, R (A, B) | water | water | 18.0 | 1026 | Chemie (HOH) |
Sequence modifications
B: 1 - 831 (UniProt: P9WFU1)
| PDB | External Database | Details |
|---|---|---|
| Trp 832 | - | expression tag |
| Lys 833 | - | expression tag |
| Leu 834 | - | expression tag |
| Ala 835 | - | expression tag |
| Ala 836 | - | expression tag |
| Ala 837 | - | expression tag |
| Leu 838 | - | expression tag |
| Glu 839 | - | expression tag |
| His 840 | - | expression tag |
| His 841 | - | expression tag |
| His 842 | - | expression tag |
| His 843 | - | expression tag |
| His 844 | - | expression tag |
| His 845 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 127595.1 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 1705.3 | |
| All* | Total formula weight | 129300.3 |
