7DAD

EPD in complex with tubulin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Tubulin alpha-1B chain	polymer	451	50204.4	2	UniProt (Q2XVP4) Pfam (PF00091) Pfam (PF03953)	Sus scrofa (Pig)	Alpha-tubulin ubiquitous,Tubulin K-alpha-1,Tubulin alpha-ubiquitous chain
2	B, D (B, D)	Tubulin beta chain	polymer	445	49999.9	2	UniProt (A0A287AGU7) Pfam (PF00091) Pfam (PF03953) UniProt (by SIFTS) (P02554)	Sus scrofa (Pig)
3	E (E)	Stathmin-4	polymer	143	16844.2	1	UniProt (P63042) Pfam (PF00836)	Mus musculus (Mouse)	Stathmin-like protein B3,RB3
4	F (F)	Tubulin tyrosine ligase	polymer	384	44378.5	1	UniProt (E1BQ43)	Gallus gallus (Chicken)
5	G, R, U (A, C, D)	GUANOSINE-5'-TRIPHOSPHATE	non-polymer		523.2	3	Chemie (GTP)
6	H, M, Q, S, X (A, B, C, F)	MAGNESIUM ION	non-polymer		24.3	5	Chemie (MG)
7	I, K, N, T (A, B, C)	CALCIUM ION	non-polymer		40.1	4	Chemie (CA)
8	J (A)	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
9	L (B)	GUANOSINE-5'-DIPHOSPHATE	non-polymer		443.2	1	Chemie (GDP)
10	O, P (B)	2-(N-MORPHOLINO)-ETHANESULFONIC ACID	non-polymer		195.2	2	Chemie (MES)
11	V (D)	EPOTHILONE D	non-polymer		491.7	1	Chemie (EPD)
12	W (F)	PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER	non-polymer		505.2	1	Chemie (ACP)

Sequence modifications

E: 5 - 145 (UniProt: P63042)

PDB	External Database	Details
Met 3	-	initiating methionine
Ala 4	-	expression tag

F: 1 - 378 (UniProt: E1BQ43)

PDB	External Database	Details
His 379	-	expression tag
His 380	-	expression tag
His 381	-	expression tag
His 382	-	expression tag
His 383	-	expression tag
His 384	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	261631.3
Non-Polymers*	Number of molecules	18
	Total formula weight	3717.4
All*	Total formula weight	265348.7

*Water molecules are not included.