7D76

Cryo-EM structure of the beclomethasone-bound adhesion receptor GPR97-Go complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Guanine nucleotide-binding protein G(o) subunit alpha	polymer	226	25286.9	1	Pfam (PF00503) UniProt (by SIFTS) (P09471)	Homo sapiens
2	B (B)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	polymer	346	38245.8	1	UniProt (P62873) Pfam (PF25391)	Homo sapiens (Human)	Transducin beta chain 1
3	C (G)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	polymer	71	7861.1	1	UniProt (P59768) Pfam (PF00631)	Homo sapiens (Human)	G gamma-I
4	D (R)	Adhesion G protein-coupled receptor G3; GPR97	polymer	561	62767.1	1	Pfam (PF01825) Pfam (PF00002) UniProt (by SIFTS) (Q86Y34)	Homo sapiens
5	E, G, H (A, R)	PALMITIC ACID	non-polymer		256.4	3	Chemie (PLM)
6	F (R)	CHOLESTEROL HEMISUCCINATE	non-polymer		486.7	1	Chemie (Y01) PubChem (65082) PubChem (363416) PubChem (500055) PubChem (13301926) PubChem (13301927) PubChem (16219150) PubChem (22210610) PubChem (45489984) PubChem (57163942) PubChem (89891013) PubChem (99567468) PubChem (124427194) PubChem (124897021) PubChem (124897020) PubChem (10005657) PubChem (130340716) PubChem (11969853) PubChem (137392566) PubChem (137496323) PubChem (155804219) PubChem (169132514) PubChem (60078761) PubChem (73440805) PubChem (99567469) PubChem (124301053) PubChem (124302591) PubChem (124303794) PubChem (124421343) PubChem (124427195) PubChem (124914595) PubChem (124914596) PubChem (131705526) PubChem (137332121) PubChem (137496357) PubChem (146157332) PubChem (154929912) PubChem (155199678) PubChem (156327905) PubChem (156426247) PubChem (156516588) PubChem (166979870) PubChem (167024614) PubChem (169132513) PubChem (170117245) PubChem (172400028)
7	I (R)	(8~{S},9~{R},10~{S},11~{S},13~{S},14~{S},16~{S},17~{R})-9-chloranyl-10,13,16-trimethyl-11,17-bis(oxidanyl)-17-(2-oxidanylethanoyl)-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one	non-polymer		408.9	1	Chemie (GXR) PubChem (2308) PubChem (6603734) PubChem (11407187) PubChem (11957468) PubChem (16218996) PubChem (22797610) PubChem (22813748) PubChem (24867475) PubChem (44339726) PubChem (46780650) PubChem (22802601) PubChem (44307635) PubChem (57368539) PubChem (69288779) PubChem (20469) PubChem (58363201) PubChem (163285100) PubChem (59567852) PubChem (67698235) PubChem (155903696) PubChem (73759810) PubChem (124514953) PubChem (124918387) PubChem (124918388) PubChem (124918389) PubChem (126968472) PubChem (129050351) PubChem (133687604) PubChem (140484649) PubChem (172012098) PubChem (172897682)
8	J, K (R)	CHOLESTEROL	non-polymer		386.7	2	Chemie (CLR) PubChem (304) PubChem (191463) PubChem (368063) PubChem (369319) PubChem (638019) PubChem (1549081) PubChem (1553803) PubChem (5283629) PubChem (5284644) PubChem (5315842) PubChem (6419195) PubChem (6994560) PubChem (7055705) PubChem (7055706) PubChem (7059398) PubChem (7059400) PubChem (7059635) PubChem (7103033) PubChem (7182477) PubChem (7182478) PubChem (9909206) PubChem (10045721) PubChem (71168115) PubChem (10134774) PubChem (10293553) PubChem (71173031) PubChem (11003580) PubChem (11025495) PubChem (11058155) PubChem (11463329) PubChem (11868624) PubChem (11868625) PubChem (11869366) PubChem (11869367) PubChem (11869368) PubChem (11869369) PubChem (12120344) PubChem (12156156) PubChem (12303135) PubChem (12303148) PubChem (12303156) PubChem (12303159) PubChem (12303160) PubChem (16219173) PubChem (16758052) PubChem (40477506) PubChem (40557614) PubChem (42579431) PubChem (42579432) PubChem (176980071) PubChem (45044259) PubChem (18640088) PubChem (1715243) PubChem (1715244) PubChem (23423981) PubChem (49853509) PubChem (44654663) PubChem (46937002) PubChem (59274407) PubChem (50990013) PubChem (68311425) PubChem (68311398) PubChem (143173313) PubChem (177156123) PubChem (5997) PubChem (1551269) PubChem (90070115) PubChem (52934537) PubChem (117965027) PubChem (6432564) PubChem (6710666) PubChem (124146240) PubChem (56621683) PubChem (7059399) PubChem (124897607) PubChem (124896959) PubChem (10861996) PubChem (132837164) PubChem (11834483) PubChem (11888915) PubChem (11888914) PubChem (57915018) PubChem (57939063) PubChem (138967089) PubChem (58428240) PubChem (58445498) PubChem (139566851) PubChem (58663286) PubChem (15939944) PubChem (59450329) PubChem (59628412) PubChem (171828367) PubChem (173516975) PubChem (59965215) PubChem (71234641) PubChem (59993755) PubChem (60001463) PubChem (66634651) PubChem (68055877) PubChem (68166463) PubChem (68315613) PubChem (70795838) PubChem (70797612) PubChem (70954610) PubChem (70957185) PubChem (71463909) PubChem (89951918) PubChem (90224410) PubChem (91298236) PubChem (101624109) PubChem (124225449) PubChem (124429284) PubChem (124909223) PubChem (124909224) PubChem (124909225) PubChem (130459183) PubChem (131992107) PubChem (139568882) PubChem (142983773) PubChem (144054483) PubChem (144209461) PubChem (144331236) PubChem (144808354) PubChem (145053568) PubChem (145157652) PubChem (145215073) PubChem (145230478) PubChem (146320991) PubChem (147857230) PubChem (154993519) PubChem (158603858) PubChem (162906452) PubChem (162906453) PubChem (162906454) PubChem (162906455) PubChem (162906456) PubChem (162906457) PubChem (163255768) PubChem (163389210) PubChem (164665303) PubChem (166553771) PubChem (166712004) PubChem (170116175) PubChem (171764280) PubChem (171817101) PubChem (171817104) PubChem (174285573)

Sequence modifications

B: 1 - 340 (UniProt: P62873)

PDB	External Database	Details
His 341	-	expression tag
His 342	-	expression tag
His 343	-	expression tag
His 344	-	expression tag
His 345	-	expression tag
His 346	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	134161.0
Non-Polymers*	Number of molecules	7
	Total formula weight	2438.2
All*	Total formula weight	136599.2

*Water molecules are not included.