7CZE

Crystal structure of Epstein-Barr virus (EBV) gHgL and in complex with the ligand binding domian (LBD) of EphA2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E, G (A, C, E, G)	Envelope glycoprotein H	polymer	662	73383.2	4	UniProt (P03231) Pfam (PF02489) Pfam (PF17488)	Epstein-Barr virus (strain B95-8) (HHV-4)	gH
2	B, D, F, H (B, D, F, H)	Envelope glycoprotein L	polymer	114	12589.2	4	UniProt (P03212) Pfam (PF11108)	Human herpesvirus 4 strain B95-8 (HHV-4)	gL
3	I, J, K, L (I, J, K, L)	Ephrin type-A receptor 2	polymer	183	21101.9	4	UniProt (P29317) Pfam (PF01404)	Homo sapiens (Human)	Epithelial cell kinase,Tyrosine-protein kinase receptor ECK
4	AA, BA, M, N, O... (H, A, B, C, D...)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	16	Chemie (NAG)

Sequence modifications

A, C, E, G: 18 - 674 (UniProt: P03231)

PDB	External Database	Details
Glu 675	-	expression tag
Glu 676	-	expression tag
Arg 677	-	expression tag
Ala 678	-	expression tag
His 679	-	expression tag

B, D, F, H: 24 - 132 (UniProt: P03212)

PDB	External Database	Details
Trp 133	-	expression tag
His 134	-	expression tag
Arg 135	-	expression tag
Gly 136	-	expression tag
Gly 137	-	expression tag

I, J, K, L: 26 - 200 (UniProt: P29317)

PDB	External Database	Details
His 201	-	expression tag
His 202	-	expression tag
His 203	-	expression tag
His 204	-	expression tag
His 205	-	expression tag
His 206	-	expression tag
His 207	-	expression tag
His 208	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	428297.0
Non-Polymers*	Number of molecules	16
	Total formula weight	3539.3
All*	Total formula weight	431836.3

*Water molecules are not included.