7CYL

Crystal structure of Karyopherin-beta2 in complex with FUS PY-NLS(P525L)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Transportin-1	polymer	868	98325.4	1	UniProt (Q92973) Pfam (PF03810) Pfam (PF25780) Pfam (PF13513) Pfam (PF25574)	Homo sapiens (Human)	Karyopherin beta-2,Importin beta-2,M9 region interaction protein,MIP
2	B (B)	RNA-binding protein FUS	polymer	54	5788.2	1	UniProt (P35637)	Homo sapiens (Human)	75 kDa DNA-pairing protein,Oncogene FUS,Oncogene TLS,POMp75,Translocated in liposarcoma protein

Sequence modifications

A: 1 - 360 (UniProt: Q92973)

PDB	External Database	Details
Gly -1	-	expression tag
Ser 0	-	expression tag

A: 368 - 890 (UniProt: Q92973)

PDB	External Database	Details
Gly 361	-	linker
Gly 362	-	linker
Ser 363	-	linker
Gly 364	-	linker
Gly 365	-	linker
Ser 366	-	linker
Gly 367	-	linker

B: 476 - 526 (UniProt: P35637)

PDB	External Database	Details
Gly 473	-	expression tag
Gly 474	-	expression tag
Ser 475	-	expression tag
Leu 525	Pro 525	variant

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	104113.6
All*	Total formula weight	104113.6

*Water molecules are not included.