7CT5

S protein of SARS-CoV-2 in complex bound with T-ACE2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C	Spike glycoprotein	polymer	1283	142502.6	3	UniProt (P0DTC2) Pfam (PF16451) Pfam (PF09408) Pfam (PF19209) Pfam (PF01601) In PDB	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)	S glycoprotein,E2,Peplomer protein
2	D, E, F	Angiotensin-converting enzyme 2	polymer	655	75010.2	3	UniProt (Q9BYF1) Pfam (PF01401) In PDB	Homo sapiens (Human)	Angiotensin-converting enzyme homolog,ACEH,Angiotensin-converting enzyme-related carboxypeptidase,ACE-related carboxypeptidase,Metalloprotease MPROT15
3	a, b, c, d, e...	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	35	In PDB GlyTouCan (G42666HT)
4	B, C, A, D, E...	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	34	Chemie (NAG)

Sequence modifications

A, B, C: 1 - 1273 (UniProt: P0DTC2)

PDB	External Database	Details
Pro 986	Lys 986	engineered mutation
Pro 987	Val 987	engineered mutation
Leu 1274	-	expression tag
Glu 1275	-	expression tag
Asp 1276	-	expression tag
Tyr 1277	-	expression tag
Lys 1278	-	expression tag
Asp 1279	-	expression tag
Asp 1280	-	expression tag
Asp 1281	-	expression tag
Asp 1282	-	expression tag
Lys 1283	-	expression tag

D, E, F: 19 - 615 (UniProt: Q9BYF1)

PDB	External Database	Details
Gly 616	-	expression tag
Ser 617	-	expression tag
Glu 618	-	expression tag
Ala 619	-	expression tag
Ala 620	-	expression tag
Ala 621	-	expression tag
Lys 622	-	expression tag
Glu 623	-	expression tag
Ala 624	-	expression tag
Ala 625	-	expression tag
Ala 626	-	expression tag
Lys 627	-	expression tag
Glu 628	-	expression tag
Ala 629	-	expression tag
Ala 630	-	expression tag
Ala 631	-	expression tag
Lys 632	-	expression tag
Glu 633	-	expression tag
Ala 634	-	expression tag
Ala 635	-	expression tag
Ala 636	-	expression tag
Lys 637	-	expression tag
Glu 638	-	expression tag
Ala 639	-	expression tag
Ala 640	-	expression tag
Ala 641	-	expression tag
Lys 642	-	expression tag
Gly 643	-	expression tag
Ser 644	-	expression tag
Gly 645	-	expression tag
Tyr 646	-	expression tag
Ile 647	-	expression tag
Pro 648	-	expression tag
Glu 649	-	expression tag
Ala 650	-	expression tag
Pro 651	-	expression tag
Arg 652	-	expression tag
Asp 653	-	expression tag
Gly 654	-	expression tag
Gln 655	-	expression tag
Ala 656	-	expression tag
Tyr 657	-	expression tag
Val 658	-	expression tag
Arg 659	-	expression tag
Lys 660	-	expression tag
Asp 661	-	expression tag
Gly 662	-	expression tag
Glu 663	-	expression tag
Trp 664	-	expression tag
Val 665	-	expression tag
Leu 666	-	expression tag
Leu 667	-	expression tag
Ser 668	-	expression tag
Thr 669	-	expression tag
Phe 670	-	expression tag
Leu 671	-	expression tag
Gly 672	-	expression tag
Ser 673	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	652538.4
Branched	Number of molecules	35
	Total formula weight	14854.0
Non-Polymers*	Number of molecules	34
	Total formula weight	7521.1
All*	Total formula weight	674913.5

*Water molecules are not included.