7CQ7

Structure of the human CLCN7-OSTM1 complex with ADP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Osteopetrosis-associated transmembrane protein 1	polymer	344	38638.0	2	UniProt (Q86WC4) Pfam (PF09777)	Homo sapiens (Human)	Chloride channel 7 beta subunit
2	C, D (C, D)	H(+)/Cl(-) exchange transporter 7	polymer	825	90906.0	2	UniProt (P51798) Pfam (PF00654) Pfam (PF00571)	Homo sapiens (Human)	Chloride channel 7 alpha subunit,Chloride channel protein 7,ClC-7
3	E, F (E, F)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
4	G, I (C, D)	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	2	Chemie (ADP)
5	H, J, K (C, D)	CHLORIDE ION	non-polymer		35.5	3	Chemie (CL)

Sequence modifications

A, B: 1 - 334 (UniProt: Q86WC4)

PDB	External Database	Details
Leu 335	-	expression tag
Glu 336	-	expression tag
His 337	-	expression tag
His 338	-	expression tag
His 339	-	expression tag
His 340	-	expression tag
His 341	-	expression tag
His 342	-	expression tag
His 343	-	expression tag
His 344	-	expression tag

C, D: 1 - 805 (UniProt: P51798)

PDB	External Database	Details
Met -19	-	initiating methionine
Ala -18	-	expression tag
Ser -17	-	expression tag
Asp -16	-	expression tag
Tyr -15	-	expression tag
Lys -14	-	expression tag
Asp -13	-	expression tag
Asp -12	-	expression tag
Asp -11	-	expression tag
Asp -10	-	expression tag
Lys -9	-	expression tag
Ala -8	-	expression tag
Ser -7	-	expression tag
Asp -6	-	expression tag
Glu -5	-	expression tag
Val -4	-	expression tag
Asp -3	-	expression tag
Ala -2	-	expression tag
Gly -1	-	expression tag
Thr 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	259088.0
Branched	Number of molecules	2
	Total formula weight	848.8
Non-Polymers*	Number of molecules	5
	Total formula weight	960.8
All*	Total formula weight	260897.6

*Water molecules are not included.