7CQ7
Structure of the human CLCN7-OSTM1 complex with ADP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0005247 | molecular_function | voltage-gated chloride channel activity |
| C | 0005254 | molecular_function | chloride channel activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005764 | cellular_component | lysosome |
| C | 0005765 | cellular_component | lysosomal membrane |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0006821 | biological_process | chloride transport |
| C | 0015108 | molecular_function | chloride transmembrane transporter activity |
| C | 0015297 | molecular_function | antiporter activity |
| C | 0016020 | cellular_component | membrane |
| C | 0030321 | biological_process | transepithelial chloride transport |
| C | 0034707 | cellular_component | chloride channel complex |
| C | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| C | 0055085 | biological_process | transmembrane transport |
| C | 1902476 | biological_process | chloride transmembrane transport |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0005247 | molecular_function | voltage-gated chloride channel activity |
| D | 0005254 | molecular_function | chloride channel activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005764 | cellular_component | lysosome |
| D | 0005765 | cellular_component | lysosomal membrane |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0006821 | biological_process | chloride transport |
| D | 0015108 | molecular_function | chloride transmembrane transporter activity |
| D | 0015297 | molecular_function | antiporter activity |
| D | 0016020 | cellular_component | membrane |
| D | 0030321 | biological_process | transepithelial chloride transport |
| D | 0034707 | cellular_component | chloride channel complex |
| D | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| D | 0055085 | biological_process | transmembrane transport |
| D | 1902476 | biological_process | chloride transmembrane transport |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 664 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000250 |
| Chain | Residue | Details |
| C | MET1-ARG126 | |
| C | ILE598-THR805 | |
| D | MET1-ARG126 | |
| D | ILE598-THR805 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 444 |
| Details | TRANSMEM: Helical => ECO:0000250 |
| Chain | Residue | Details |
| C | TRP127-ILE159 | |
| C | TYR579-PHE597 | |
| D | TRP127-ILE159 | |
| D | PHE174-ILE197 | |
| D | ARG223-GLY241 | |
| D | GLU247-GLY264 | |
| D | PHE322-VAL341 | |
| D | ILE375-ARG405 | |
| D | PRO410-ILE432 | |
| D | PRO487-LEU507 | |
| D | GLY512-LEU535 | |
| C | PHE174-ILE197 | |
| D | TYR579-PHE597 | |
| C | ARG223-GLY241 | |
| C | GLU247-GLY264 | |
| C | PHE322-VAL341 | |
| C | ILE375-ARG405 | |
| C | PRO410-ILE432 | |
| C | PRO487-LEU507 | |
| C | GLY512-LEU535 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 104 |
| Details | INTRAMEM: Helical => ECO:0000250 |
| Chain | Residue | Details |
| C | ILE206-LEU213 | |
| D | THR563-THR574 | |
| C | PHE288-ALA300 | |
| C | PRO304-LEU312 | |
| C | GLY545-ILE559 | |
| C | THR563-THR574 | |
| D | ILE206-LEU213 | |
| D | PHE288-ALA300 | |
| D | PRO304-LEU312 | |
| D | GLY545-ILE559 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 10 |
| Details | INTRAMEM: Note=Loop between two helices => ECO:0000250 |
| Chain | Residue | Details |
| C | VAL560-MET562 | |
| C | SER575-THR578 | |
| D | VAL560-MET562 | |
| D | SER575-THR578 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 10 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| C | SER204 | |
| D | THR783 | |
| C | PHE514 | |
| C | TYR602 | |
| C | HIS658 | |
| C | THR783 | |
| D | SER204 | |
| D | PHE514 | |
| D | TYR602 | |
| D | HIS658 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | SITE: Mediates proton transfer from the outer aqueous phase to the interior of the protein; involved in linking H(+) and Cl(-) transport => ECO:0000250 |
| Chain | Residue | Details |
| C | GLU247 | |
| D | GLU247 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | SITE: Mediates proton transfer from the protein to the inner aqueous phase => ECO:0000250 |
| Chain | Residue | Details |
| C | GLU314 | |
| A | ASN274 | |
| B | ASN93 | |
| B | ASN128 | |
| B | ASN135 | |
| B | ASN163 | |
| B | ASN177 | |
| B | ASN184 | |
| B | ASN194 | |
| B | ASN216 | |
| B | ASN263 | |
| D | GLU314 | |
| B | ASN274 | |
| A | ASN135 | |
| A | ASN163 | |
| A | ASN177 | |
| A | ASN184 | |
| A | ASN194 | |
| A | ASN216 | |
| A | ASN263 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:O70496 |
| Chain | Residue | Details |
| C | SER9 | |
| D | SER9 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| C | SER60 | |
| D | SER60 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| C | SER801 | |
| D | SER801 |
