7CM3
Cryo-EM structure of human NALCN in complex with FAM155A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Sodium leak channel non-selective protein | polymer | 1765 | 203617.0 | 1 | UniProt (Q8IZF0) Pfam (PF00520) | Homo sapiens (Human) | CanIon,Voltage gated channel-like protein 1 |
| 2 | B (B) | Transmembrane protein FAM155A | polymer | 485 | 54604.4 | 1 | UniProt (B1AL88) | Homo sapiens (Human) | |
| 3 | C (C) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 4 | D (D) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 5 | E, P (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 6 | F, G, H, I, J... (A) | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 790.1 | 10 | Chemie (PC1) |
Sequence modifications
A: 1 - 1738 (UniProt: Q8IZF0)
B: 1 - 458 (UniProt: B1AL88)
| PDB | External Database | Details |
|---|---|---|
| Leu 1739 | - | expression tag |
| Glu 1740 | - | expression tag |
| Asp 1741 | - | expression tag |
| Glu 1742 | - | expression tag |
| Val 1743 | - | expression tag |
| Asp 1744 | - | expression tag |
| Ala 1745 | - | expression tag |
| Gly 1746 | - | expression tag |
| Ser 1747 | - | expression tag |
| Asp 1748 | - | expression tag |
| Tyr 1749 | - | expression tag |
| Lys 1750 | - | expression tag |
| Asp 1751 | - | expression tag |
| Asp 1752 | - | expression tag |
| Asp 1753 | - | expression tag |
| Asp 1754 | - | expression tag |
| Lys 1755 | - | expression tag |
| Gly 1756 | - | expression tag |
| Ser 1757 | - | expression tag |
| Asp 1758 | - | expression tag |
| Tyr 1759 | - | expression tag |
| Lys 1760 | - | expression tag |
| Asp 1761 | - | expression tag |
| Asp 1762 | - | expression tag |
| Asp 1763 | - | expression tag |
| Asp 1764 | - | expression tag |
| Lys 1765 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Leu 459 | - | expression tag |
| Glu 460 | - | expression tag |
| Asp 461 | - | expression tag |
| Glu 462 | - | expression tag |
| Val 463 | - | expression tag |
| Asp 464 | - | expression tag |
| Ala 465 | - | expression tag |
| Gly 466 | - | expression tag |
| Ser 467 | - | expression tag |
| Asp 468 | - | expression tag |
| Tyr 469 | - | expression tag |
| Lys 470 | - | expression tag |
| Asp 471 | - | expression tag |
| Asp 472 | - | expression tag |
| Asp 473 | - | expression tag |
| Asp 474 | - | expression tag |
| Lys 475 | - | expression tag |
| Gly 476 | - | expression tag |
| Ser 477 | - | expression tag |
| Asp 478 | - | expression tag |
| Tyr 479 | - | expression tag |
| Lys 480 | - | expression tag |
| Asp 481 | - | expression tag |
| Asp 482 | - | expression tag |
| Asp 483 | - | expression tag |
| Asp 484 | - | expression tag |
| Lys 485 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 258221.4 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 1010.9 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 8343.9 | |
| All* | Total formula weight | 267576.2 |
