Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7CM3

Cryo-EM structure of human NALCN in complex with FAM155A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0005248	molecular_function	voltage-gated sodium channel activity
A	0005261	molecular_function	monoatomic cation channel activity
A	0005272	molecular_function	sodium channel activity
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006814	biological_process	sodium ion transport
A	0016020	cellular_component	membrane
A	0022840	molecular_function	leak channel activity
A	0032224	biological_process	positive regulation of synaptic transmission, cholinergic
A	0032230	biological_process	positive regulation of synaptic transmission, GABAergic
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0034702	cellular_component	monoatomic ion channel complex
A	0035725	biological_process	sodium ion transmembrane transport
A	0055085	biological_process	transmembrane transport
A	0060075	biological_process	regulation of resting membrane potential
A	0070588	biological_process	calcium ion transmembrane transport
A	0071805	biological_process	potassium ion transmembrane transport
A	0098908	biological_process	regulation of neuronal action potential
B	0005886	cellular_component	plasma membrane
B	0015275	molecular_function	stretch-activated, monoatomic cation-selective, calcium channel activity
B	0035725	biological_process	sodium ion transmembrane transport
B	0098703	biological_process	calcium ion import across plasma membrane
B	0098908	biological_process	regulation of neuronal action potential

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=S1 of repeat I","evidences":[{"source":"PubMed","id":"32698188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XIW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	253
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"32698188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XIW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	24
Details	Transmembrane: {"description":"Helical; Name=S2 of repeat I","evidences":[{"source":"PubMed","id":"32698188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XIW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=S3 of repeat I","evidences":[{"source":"PubMed","id":"32698188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XIW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Voltage-sensor; Name=S4 of repeat I","evidences":[{"source":"PubMed","id":"32698188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XIW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	120
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"32698188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XIW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	25
Details	Transmembrane: {"description":"Helical; Name=S5 of repeat I","evidences":[{"source":"PubMed","id":"32698188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XIW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	76
Details	Intramembrane: {"description":"Pore-forming","evidences":[{"source":"PubMed","id":"32698188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XIW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	27
Details	Transmembrane: {"description":"Helical; Name=S6 of repeat I","evidences":[{"source":"PubMed","id":"32698188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XIW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=S1 of repeat II","evidences":[{"source":"PubMed","id":"32698188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XIW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=S2 of repeat II","evidences":[{"source":"PubMed","id":"32698188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XIW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=S3 of repeat II","evidences":[{"source":"PubMed","id":"32698188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XIW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	19
Details	Transmembrane: {"description":"Helical; Voltage-sensor; Name=S4 of repeat II","evidences":[{"source":"PubMed","id":"32698188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XIW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	27
Details	Transmembrane: {"description":"Helical; Name=S5 of repeat II","evidences":[{"source":"PubMed","id":"32698188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XIW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	29
Details	Transmembrane: {"description":"Helical; Name=S6 of repeat II","evidences":[{"source":"PubMed","id":"32698188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XIW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	19
Details	Transmembrane: {"description":"Helical; Name=S1 of repeat III","evidences":[{"source":"PubMed","id":"32698188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XIW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	23
Details	Transmembrane: {"description":"Helical; Name=S2 of repeat III","evidences":[{"source":"PubMed","id":"32698188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XIW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	24
Details	Transmembrane: {"description":"Helical; Name=S3 of repeat III","evidences":[{"source":"PubMed","id":"32698188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XIW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Voltage-sensor; Name=S4 of repeat III","evidences":[{"source":"PubMed","id":"32698188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XIW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	23
Details	Transmembrane: {"description":"Helical; Name=S5 of repeat III","evidences":[{"source":"PubMed","id":"32698188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XIW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	29
Details	Transmembrane: {"description":"Helical; Name=S6 of repeat III","evidences":[{"source":"PubMed","id":"32698188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XIW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	16
Details	Transmembrane: {"description":"Helical; Name=S1 of repeat IV","evidences":[{"source":"PubMed","id":"32698188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XIW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	23
Details	Transmembrane: {"description":"Helical; Name=S2 of repeat IV","evidences":[{"source":"PubMed","id":"32698188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XIW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI24
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=S3 of repeat IV","evidences":[{"source":"PubMed","id":"32698188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XIW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI25
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Voltage-sensor; Name=S4 of repeat IV","evidences":[{"source":"PubMed","id":"32698188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XIW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI26
Number of Residues	25
Details	Transmembrane: {"description":"Helical; Name=S5 of repeat IV","evidences":[{"source":"PubMed","id":"32698188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XIW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI27
Number of Residues	26
Details	Transmembrane: {"description":"Helical; Name=S6 of repeat IV","evidences":[{"source":"PubMed","id":"32698188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XIW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI28
Number of Residues	3
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"33203861","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CM3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI29
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"32698188","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33203861","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XIW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7CM3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)