7CJB

VHL recognizes hydroxyproline in RIPK1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, E, I, M	von Hippel-Lindau disease tumor suppressor	polymer	163	18725.3	4	UniProt (P40337) Pfam (PF01847) Pfam (PF17211) In PDB	Homo sapiens (Human)	Protein G7,pVHL
2	B, F, J, N	Elongin-B	polymer	122	13397.9	4	UniProt (Q15370) Pfam (PF00240) In PDB	Homo sapiens (Human)	EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2
3	C, G, K, O	Elongin-C	polymer	100	11141.7	4	Pfam (PF03931) UniProt (by SIFTS) (Q15369) In PDB	Homo sapiens (Human)
4	D, H, L, P	THR-LEU-TYR-TYR-MET-ALA-PRO-GLU-HIS-LEU-ASN-ASP-VAL-ASN-ALA	polymer	15	1767.9	4	UniProt (Q13546) In PDB	Homo sapiens	15-mer peptide from Receptor-interacting serine/threonine-protein kinase 1
5	E, I	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)

Sequence modifications

A, E, I, M: 55 - 213 (UniProt: P40337)

PDB	External Database	Details
Gly 51	-	expression tag
Pro 52	-	expression tag
Gly 53	-	expression tag
Ser 54	-	expression tag

B, F, J, N: 1 - 118 (UniProt: Q15370)

PDB	External Database	Details
Gly -3	-	expression tag
Pro -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag
Ala 60	Cys 60	conflict
Ser 89	Cys 89	conflict

Contents of the asymmetric unit

Polymers	Number of chains	16
	Total formula weight	180131.4
Non-Polymers*	Number of molecules	2
	Total formula weight	184.2
All*	Total formula weight	180315.6

*Water molecules are not included.